BGB-3245 is a small molecule commercialized by SpringWorks Therapeutics, with a leading Phase II program in Solid Tumor. According to Globaldata, it is involved in 3 clinical trials, of which 2 are ongoing, and 1 is planned. GlobalData uses proprietary data and analytics to provide a complete picture of BGB-3245’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for BGB-3245 is expected to reach an annual total of $13 mn by 2034 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
BGB-3245 is under development for the treatment of solid tumors including colorectal cancer, pancreatic participants, non-small cell lung cancer and bile duct cancer (cholangiocarcinoma) and endometrial cancer. This is a next generation RAF dimer inhibitors. The drug candidate targets a proto-oncogene B-Raf.
It was under development for melanoma.
SpringWorks Therapeutics Overview
SpringWorks Therapeutics is a drug development company that develops therapeutic medicines for various diseases. The company’s pipeline products include Nirogacestat, MEK ½ Inhibitor, Senicapoc and FAAH Inhibitor. Its Nirogacestat is a gamma-secretase inhibitor used for the treatment of Desmoid tumors. SpringWorks Therapeutics’ Senicapoc is a Gardos channel blocker used for the treatment of hereditary xerocytosis. The company’s FAAH Inhibitor is used for the treatment of post-traumatic stress disorder. It partners with biopharmaceutical companies, scientists, patient groups and philanthropists. SpringWorks Therapeutics is headquartered in Stamford, Connecticut, the US.
The operating loss of the company was US$280.7 million in FY2022, compared to an operating loss of US$173.5 million in FY2021. The net loss of the company was US$277.4 million in FY2022, compared to a net loss of US$173.9 million in FY2021.
For a complete picture of BGB-3245’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.