Bidridistrogene xeboparvovec is a gene therapy commercialized by Sarepta Therapeutics, with a leading Phase III program in Limb-Girdle Muscular Dystrophy. According to Globaldata, it is involved in 3 clinical trials, which are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of Bidridistrogene xeboparvovec’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for Bidridistrogene xeboparvovec is expected to reach an annual total of $218 mn by 2037 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Bidridistrogene xeboparvovec Overview
bidridistrogene xeboparvovec (SRP-9003) is under development for the treatment of limb-girdle muscular dystrophy type 2E (LGMD2E). It is administered by intravenous route. The drug candidate comprises of self-complementary recombinant adeno-associated virus serotype rhesus 74 (AAVrh.74) encoding human beta-sarcoglycan (SGCB) gene. It acts by targeting SGCB gene.
It was also under development for the treatment of limb-girdle muscular dystrophy type 2E (LGMD2E).
Sarepta Therapeutics Overview
Sarepta Therapeutics (Sarepta) discovers and develops unique RNA-targeted medicines to treat rare diseases. The company develops its pipeline products using its multi-platform Precision Genetic Medicine Engine in gene therapy, RNA, and gene editing. The company’s platform is based on its pioneering work with phosphorodiamidate morpholino oligomer (PMO) chemistries. Its commercial products include Exondys 51, Vyondys 53 and Amondys 45 indicated for the treatment of Duchenne muscular dystrophy (DMD) in patients who have a confirmed mutation of the DMD gene. Its pipeline product includes SRP-9001, SRP-5051, SRP-9003 and SRP-5045 indicated for the treatment of DMD, limb-girdle muscular dystrophies (LGDMs) and other neuromuscular and central nervous system disorders. Sarepta is headquartered in Cambridge, Massachusetts, the US.
The company reported revenues of (US Dollars) US$933 million for the fiscal year ended December 2022 (FY2022), an increase of 32.9% over FY2021. The operating loss of the company was US$664.2 million in FY2022, compared to an operating loss of US$362.2 million in FY2021. The net loss of the company was US$703.5 million in FY2022, compared to a net loss of US$418.8 million in FY2021.
The company reported revenues of US$331.8 million for the third quarter ended September 2023, an increase of 27% over the previous quarter.
For a complete picture of Bidridistrogene xeboparvovec’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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