BMS-986288 is under clinical development by Bristol-Myers Squibb and currently in Phase II for Melanoma. According to GlobalData, Phase II drugs for Melanoma have a 27% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how BMS-986288’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
BMS-986288 overview
BMS-986288 was under development for the treatment of advanced solid tumors including head and neck cancer squamous cell carcinoma, melanoma, triple-negative breast cancer (TNBC), renal cell carcinoma, transitional cell carcinoma (urothelial cell carcinoma), gastric cancer, esophageal cancer, cervical cancer. It is being developed based on a modified version of ipilimumab. The drug candidate targets CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4). The drug candidate is designed using the Probody platform. Probodies are fully recombinant, masked antibodies that remain inert in healthy tissue but are activated specifically in the disease microenvironment.
It was under development for non-small cell lung cancer and colorectal cancer.
Bristol-Myers Squibb overview
Bristol-Myers Squibb (BMS) is a specialty biopharmaceutical company that is engaged in discovery, development, licensing and manufacturing, marketing, distribution and sale of medicines and related medical products to patients with serious diseases. Its primary focus is on cancer, immunology, cardiovascular, and fibrotic therapeutic projects. The company offers its products across the world to wholesalers, retail pharmacies, medical professionals, hospitals and government entities. BMS provides its products in the US, Europe, and Japan. The company conducts research to focus on the discovery and development of novel medicines that address serious diseases in areas of significant unmet medical need. BMS is headquartered in Princeton, New Jersey, the US.
For a complete picture of BMS-986288’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
