Cevidoplenib is under clinical development by Genosco and currently in Phase II for Idiopathic Thrombocytopenic Purpura (Immune Thrombocytopenic Purpura). According to GlobalData, Phase II drugs for Idiopathic Thrombocytopenic Purpura (Immune Thrombocytopenic Purpura) have a 65% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Cevidoplenib’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Cevidoplenib overview

Cevidoplenib (SKIO-703) is under development for the treatment of idiopathic thrombocytopenic purpura, systemic lupus erythematosus, acquired (autoimmune) hemolytic anemia, psoriasis, anti-neutrophil cytoplasmic antibody-associated vasculitis (ANCA Vasculitis). It is a mesylate salt of SKI-O-592. It is administered through oral route. The drug candidate is a pyrido [4,3,-d] pyrimidin-5-one derivative which targets spleen tyrosine kinase (Syk), a key mediator of immunoreceptor signaling in various cell types. It was also under development for the treatment of rheumatoid arthritis.

Genosco overview

Genosco a subsidiary of Oscotec Inc, is a clinical-stage biotechnology company which offers discovery and development of novel small-molecule drugs. The company develops small molecule drugs for treatment of human diseases. Its products comprise inhibitors within signal networks of SYK, FLT3 and LRRK2. Genosco offers SYK inhibitor for rheumatoid arthritis, the FLT3 inhibitor for acute myeloid leukemia, and LRRK2 selective inhibitors for the treatment of Parkinson’s disease. The company operates in the areas of medicinal chemistry, structural and computational drug discovery design, cell biology, pharmacology and also drug metabolism. It operates through collaborations with other research institutions. Genosco is headquartered in Cambridge, Massachusetts, the US.

For a complete picture of Cevidoplenib’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 20 February 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.