Cinacalcet hydrochloride is a Small Molecule owned by Takeda Pharmaceutical, and is involved in 48 clinical trials, of which 47 were completed, and 1 is ongoing.

Cinacalcet is calcium sensing receptor agonist. The calcium-sensing receptor on the surface of the chief cell of the parathyroid gland is the principal regulator of parathyroid hormone (PTH) synthesis and secretion.  Hyperparathyroidism with CKD is associated with increased PTH and derangements in calcium and phosphorus metabolism. The drug candidate directly lowers PTH levels by increasing the sensitivity of the calcium-sensing receptor to extracellular calcium. The reduction in PTH is associated with a concomitant decrease in serum calcium levels.

The revenue for Cinacalcet hydrochloride is expected to reach a total of $326m through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Cinacalcet hydrochloride NPV Report.

Cinacalcet hydrochloride was originated by Shire-NPS Pharmaceuticals and is currently owned by Takeda Pharmaceutical. Amgen and Kyowa Kirin are the other companies associated in development or marketing of Cinacalcet hydrochloride.

Cinacalcet hydrochloride Overview

Cinacalcet hydrochloride (Sensipar/ Mimpara/ Regpara) is a calcimimetic agent that mimics the action of calcium in the body. It is formulated as tablets and film coated tablets for oral administration. Sensipar is indicated for the treatment of secondary hyperparathyroidism (HPT) in patients with end-stage kidney failure, reduction of hypercalcaemia. Sensipar is indicated for the treatment of hypercalcemia in adult patients with Parathyroid Carcinoma. Sensipar is indicated for the treatment of hypercalcemia in adult patients with primary HPT for whom parathyroidectomy would be indicated on the basis of serum calcium levels, but who are unable to undergo  parathyroidectomy. Mimpara also indicated for the treatment of secondary hyperparathyroidism (HPT) in children aged three years and older with end-stage renal disease (ESRD) on maintenance dialysis therapy in whom secondary HPT is not adequately controlled with standard of care therapy.

Cinacalcet hydrochloride was under development for the treatment of secondary hyperparathyroidism in pediatric patients with chronic kidney disease receiving dialysis in the U.S.

Amgen Overview

Amgen is a biotechnology company, which discovers, develops, manufactures, and markets innovative human medicines to treat patients suffering from serious diseases. It develops novel medicines in six focused disease areas including cardiovascular diseases, oncology/hematology, inflammation, bone health, neurological disorders and nephrology. The company develops products using advanced human genetics to unravel the difficulties of disease and understand the fundamentals of human biology. Amgen sells products primarily to pharmaceutical wholesale distributors in the US. It also markets certain products directly to consumers through direct-to-consumer channels such as print, television and online media. Amgen is headquartered in Thousand Oaks, California, the US.

The company reported revenues of (US Dollars) US$25,979 million for the fiscal year ended December 2021 (FY2021), an increase of 2.2% over FY2020. In FY2021, the company’s operating margin was 29.4%, compared to an operating margin of 35.9% in FY2020. In FY2021, the company recorded a net margin of 22.7%, compared to a net margin of 28.6% in FY2020. The company reported revenues of US$6,652 million for the third quarter ended September 2022, an increase of 0.9% over the previous quarter.

Quick View – Cinacalcet hydrochloride

Report Segments
  • Innovator (NME)
Drug Name
  • Cinacalcet hydrochloride
Administration Pathway
  • Oral
Therapeutic Areas
  • Hormonal Disorders
  • Nutritional Disorders
Key Companies
Highest Development Stage
  • Marketed

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, potential applicable patients, drug margins, company expenses, and pricing estimates. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate rNPV, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA)and phase transition success rate(PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.