Enoblituzumab is under clinical development by MacroGenics and currently in Phase I for Metastatic Melanoma. According to GlobalData, Phase I drugs for Metastatic Melanoma have an 82% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how Enoblituzumab’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Enoblituzumab overview

Enoblituzumab (MGA271) is under development for the treatment of neuroblastoma, osteosarcoma, ewing sarcoma, wilms' tumor (nephroblastoma), rhabdomyosarcoma, recurrent head and neck cancer squamous cell carcinoma, non-small cell lung cancer, metastatic melanoma, head and neck cancer squamous cell carcinoma, and prostate cancer. The therapeutic candidate is a monospecific, bivalent humanized IgG1/kappa monoclonal antibody acts by targeting B7-H3.

It was under development for the treatment of solid tumors, transitional cell cancer (urothelial cell cancer), bladder carcnioma, melanoma, squamous non-small cell lung cancer, malignant mesothelioma, thyroid cancer, pancreatic cancer, ovarian cancer, colon cancer, soft tissue sarcoma, triple-negative breast cancer, metastatic renal cell carcinoma, ureter cancer, urethral cancer, prostate cancer and recurrent head and neck cancer squamous cell carcinoma.

MacroGenics overview

MacroGenics is a biopharmaceutical company which focuses on the development and delivery of novel antibody-based therapeutics for the treatment of cancer, infectious diseases and autoimmune disorders. Its product pipeline includes candidates for the treatment of solid tumors, breast and gastroesophageal cancers, type 1 diabetes, HIV, DART product candidates for the treatment of acute myeloid leukemia and myelodysplastic syndrome; and b-cell malignancies. The company’s product candidates are based on proprietary technology platforms, namely, Cancer Stem Cell Platform, Dual-Affinity Re-Targeting (or DART) and TRIDENT Platform and FC Optimization Platform. It works in collaboration with various pharmaceutical and biotechnology companies to leverage its technology platforms and protein engineering capabilities for development. MacroGenics is headquartered in Rockville, Maryland, the US.

For a complete picture of Enoblituzumab’s drug-specific PTSR and LoA scores, buy the report here.

GlobalData

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.