Heidelberg Pharma has patented a method for synthesizing amanitin derivatives with an amino group at position 6′ of the central tryptophan moiety. The patent also covers the use of these derivatives in conjugates for treating various cancers, including breast, pancreatic, and prostate cancer, among others. GlobalData’s report on Heidelberg Pharma gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Heidelberg Pharma, Personalized cancer vaccines was a key innovation area identified from patents. Heidelberg Pharma's grant share as of February 2024 was 51%. Grant share is based on the ratio of number of grants to total number of patents.
Treating cancer with amino-substituted amanitin derivative conjugates
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A recently granted patent (Publication Number: US11926631B2) discloses a method for treating cancer in patients by administering a conjugate containing an amanitin derivative with a 6'-amino-substituted tryptophan moiety, a target-binding moiety, and optionally a linker. The cancer types targeted by this method include breast cancer, pancreatic cancer, cholangiocarcinoma, colorectal cancer, prostate cancer, leukemia, and malignant lymphoma, all of which are responsive to the inhibition of mammalian RNA polymerase II.
Furthermore, the patent also covers a method for treating cancer by administering a pharmaceutical composition containing a conjugate with similar components as mentioned earlier. The cancer types eligible for treatment under this method are the same as the previous one, and they must be responsive to the inhibition of mammalian RNA polymerase II. The patent specifies the selection of amanitin derivatives, including S-desoxy-6'-amino-amanin, 6'-amino-amanin, S-desoxy-6'-amino-amaninamide, and 6'-amino-amaninamide, for the effective treatment of cancer in patients.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
