Immunocore has been granted a patent for a method of obtaining T cell receptors (TCRs) that specifically bind to a peptide antigen. The method involves screening a library of particles displaying a variety of TCRs, with the TCRs consisting of specific alpha and beta chain variable domains. The TCRs do not include certain gene products and must include more than one TRAV gene product and/or more than one TRBV gene product. The TCRs are attached to phage particles, ribosomes, yeast cells, or mammalian cells. The method includes panning the library, repeating the process, screening the identified phage clones, and identifying a TCR that specifically binds the peptide antigen. GlobalData’s report on Immunocore gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Immunocore, Peptide pharmacophores was a key innovation area identified from patents. Immunocore's grant share as of September 2023 was 30%. Grant share is based on the ratio of number of grants to total number of patents.
Method of obtaining t cell receptor for peptide antigen
A recently granted patent (Publication Number: US11739441B2) describes a method for obtaining a T cell receptor (TCR) that specifically binds to a peptide antigen. The method involves screening a library of particles displaying a variety of TCRs with the peptide antigen. The TCRs in the library consist of an alpha chain and a beta chain, with the beta chain specifically not including certain gene products. The library may contain multiple TRAV gene products and/or multiple TRBV gene products. The TCRs are covalently attached to the particles, which can be phage particles, ribosomes, yeast cells, or mammalian cells.
The method includes several steps. First, the library is panned using the peptide antigen as the target. This step is repeated one or more times to increase the chances of identifying TCRs that specifically bind to the antigen. Next, the phage clones identified in the previous steps are screened to further narrow down the selection. Finally, a TCR that specifically binds to the peptide antigen is identified.
This patent provides a novel approach to obtaining T cell receptors that have a specific binding affinity for a peptide antigen. By using a library of particles displaying a variety of TCRs and screening them with the antigen, the method allows for the identification of TCRs that meet the desired criteria. The exclusion of certain gene products in the beta chain adds specificity to the selection process.
The use of different types of particles, such as phage particles, ribosomes, yeast cells, or mammalian cells, provides flexibility in the implementation of the method. This allows researchers to choose the most suitable platform for their specific needs.
Overall, this patent presents a valuable method for obtaining T cell receptors with specific binding properties. The approach described in the patent has the potential to contribute to the development of targeted therapies and diagnostics in the field of immunology.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
