Inetagugene geperpavec is under clinical development by Krystal Biotech and currently in Phase II for Harlequin Ichthyosis (Autosomal Recessive Congenital Ichthyosis 4B). According to GlobalData, Phase II drugs for Harlequin Ichthyosis (Autosomal Recessive Congenital Ichthyosis 4B) does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Inetagugene geperpavec LoA Report. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Inetagugene geperpavec overview
KB-105 is under development for the treatment of TGM-1-deficient autosomal recessive congenital ichthyosis (ARCI). The drug candidate is administered through topical route formulated as gel and acts by targeting transglutaminase 1 (TGM-1) enzyme. It is developed based on skin TARgeted delivery (STAR-D) platform. It comprises of engineered Herpes simplex virus 1 vector.
Krystal Biotech overview
Krystal Biotech is a gene therapy company that carries out the discovery, development, and commercialization of genetic medicines to treat diseases with high unmet medical needs, especially dermatological diseases. The company’s only marketed product is VYJUVEK/B-VEC (bercolagene telserpavec), which is a gene therapy for the treatment of dystrophic epidermolysis bullosa (DEB). Krystal Biotech uses its patented gene therapy technology platform based on engineered HSV-1 to create vectors that deliver therapeutic transgenes to cells of interest in multiple organ systems. The company’s pipeline products include KB105, KB407, KB104, KB408, and KB707. Krystal Biotech is headquartered in Pittsburgh, Pennsylvania, the US.
For a complete picture of Inetagugene geperpavec’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
