The pharmaceutical industry continues to be a hotbed of innovation. Activity is driven by the evolution of new treatment paradigms, and the gravity of unmet needs, as well as the growing importance of technologies such as pharmacogenomics, digital therapeutics, and artificial intelligence. In the last three years alone, there have been over 787,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Genomics in pharma: T-Cell culturingBuy the report here.

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According to GlobalData’s Technology Foresights, which uses over 668,000 patents to analyze innovation intensity for the pharmaceutical industry, there are 80+ innovation areas that will shape the future of the industry.

T-cell culturing is a key innovation area in genomics

Optimized culture conditions for T-cell expansion are elusive, as many different factors contribute to the eventual outcome. T-cell stimulation and co-stimulation methods, different cytokines, growth media and serum, oxygen concentration, ambient pH, initial seeding density, and a static or dynamic culture are all factors that influence the outcome of T-cell expansion. To generate polyclonal T-cells, resting T-cells must first be activated with primary and secondary signals from CD3 and CD28 stimulation, respectively. Activation of T-cells can be achieved using an anti-CD3 antibody (OKT3) and irradiated feeder cells. However, a more accessible strategy for activating T-cells is by adding small magnetic beads coated with anti-CD3/CD28 antibodies. Proliferation of T-cells requires growth factors supplied by the medium and serum. One of the growth factors is interleukin-2 (IL-2), which by binding to its receptor, promotes polyclonal proliferation of T-cells by binding to its cell surface receptor.

GlobalData’s analysis also uncovers the companies at the forefront of each innovation area and assesses the potential reach and impact of their patenting activity across different applications and geographies.  According to GlobalData, there are 420+ companies, spanning technology vendors, established pharmaceutical companies, and up-and-coming start-ups engaged in the development and application of T-cell culturing.

Key players in T-cell culturing – a disruptive innovation in the pharmaceutical industry

‘Application diversity’ measures the number of applications identified for each patent. It broadly splits companies into either ‘niche’ or ‘diversified’ innovators.

‘Geographic reach’ refers to the number of countries each patent is registered in. It reflects the breadth of geographic application intended, ranging from ‘global’ to ‘local’.

Patent volumes related to T-cell culturing

Company Total patents (2010 - 2022) Premium intelligence on the world's largest companies
Immatics 848 Unlock Company Profile
Johnson & Johnson 567 Unlock Company Profile
Bristol-Myers Squibb 405 Unlock Company Profile
Iovance Biotherapeutics 383 Unlock Company Profile
Cellectis 213 Unlock Company Profile
Fujifilm 211 Unlock Company Profile
OncoTherapy Science 205 Unlock Company Profile
ViaCyte 166 Unlock Company Profile
Fate Therapeutics 164 Unlock Company Profile
Immunovative Therapies 150 Unlock Company Profile
Astellas Pharma 142 Unlock Company Profile
Fred Hutchinson Cancer Research Center 110 Unlock Company Profile
Takeda Pharmaceutical 104 Unlock Company Profile
Gilead Sciences 91 Unlock Company Profile
Memorial Sloan Kettering Cancer Center 90 Unlock Company Profile
Lonza Group 84 Unlock Company Profile
BioNTech 76 Unlock Company Profile
Sangamo Therapeutics 70 Unlock Company Profile
Ministry of Trade and Industry, Singapore 69 Unlock Company Profile
Allele Biotechnology and Pharmaceuticals 57 Unlock Company Profile
Children's Medical Center 54 Unlock Company Profile
East-West Capital Partners 54 Unlock Company Profile
Children’s National Health System 52 Unlock Company Profile
Miltenyi Biotec 52 Unlock Company Profile
I'rom Group 51 Unlock Company Profile
CRISPR Therapeutics 49 Unlock Company Profile
Gamida Cell 46 Unlock Company Profile
Seattle Children's Hospital 46 Unlock Company Profile
Takara 45 Unlock Company Profile
PolyBioCept 45 Unlock Company Profile
Thermo Fisher Scientific 44 Unlock Company Profile
Genesis Technologies 42 Unlock Company Profile
WindMIL Therapeutics 42 Unlock Company Profile
Mesoblast 41 Unlock Company Profile
Geneius Biotechnology 40 Unlock Company Profile
Adicet Bio 39 Unlock Company Profile
Taiga Biotechnologies 39 Unlock Company Profile
bluebird bio 39 Unlock Company Profile
Centre National de la Recherche Scientifique 38 Unlock Company Profile
Assistance Publique - Hopitaux de Paris 38 Unlock Company Profile
Editas Medicine 37 Unlock Company Profile
Athenex 36 Unlock Company Profile
Novartis 36 Unlock Company Profile
Cedars-Sinai Health System 35 Unlock Company Profile
Cellscript 35 Unlock Company Profile
F. Hoffmann-La Roche 35 Unlock Company Profile
GI Cell 33 Unlock Company Profile
Poseida Therapeutics 33 Unlock Company Profile
BioLamina 33 Unlock Company Profile
NEW HOPE, CITY OF 33 Unlock Company Profile

Source: GlobalData Patent Analytics

Immatics is the leading patent filer in T-cell culturing. Immatics is a biopharmaceutical company focused on the development of T-cell immunotherapies to treat cancer. Immatics is headquartered in Tuebingen, Germany. Johnson & Johnson and Bristol-Myers Squibb are the other key patent filers in T-cell culturing.

In terms of application diversity, Immatics is the top company, followed by Seattle Children's Hospital and Immunovative Therapies. By means of geographic reach, BioLamina holds the top position. Whilst Immatics and East-West Capital Partners stand in second and third positions, respectively.

To further understand the key themes and technologies disrupting the pharmaceutical industry, access GlobalData’s latest thematic research report on Genomics.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Patent Analytics tracks patent filings and grants from official offices around the world. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.