KB-707 is under clinical development by Krystal Biotech and currently in Phase I for Osteosarcoma. According to GlobalData, Phase I drugs for Osteosarcoma have an 89% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how KB-707’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
KB-707 overview
KB-707 is under development for the treatment of solid tumors, non-small cell lung cancer, metastatic melanoma and osteosarcoma. The therapeutic candidate comprises of modified HSV-1 that delivers gene encoding interleukin 2 (IL 2) and interleukin 12 (IL 12). It is administered through inhalational route and intratumor route in the form of solution.
Krystal Biotech overview
Krystal Biotech is a gene therapy company that carries out the discovery, development, and commercialization of genetic medicines to treat diseases with high unmet medical needs, especially dermatological diseases. The company’s only marketed product is VYJUVEK/B-VEC (bercolagene telserpavec), which is a gene therapy for the treatment of dystrophic epidermolysis bullosa (DEB). Krystal Biotech uses its patented gene therapy technology platform based on engineered HSV-1 to create vectors that deliver therapeutic transgenes to cells of interest in multiple organ systems. The company’s pipeline products include KB105, KB407, KB104, KB408, and KB707. Krystal Biotech is headquartered in Pittsburgh, Pennsylvania, the US.
For a complete picture of KB-707’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
