KB-707 is under clinical development by Krystal Biotech and currently in Phase I for Osteosarcoma. According to GlobalData, Phase I drugs for Osteosarcoma have an 89% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how KB-707’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

KB-707 overview

KB-707 is under development for the treatment of solid tumors, non-small cell lung cancer, metastatic melanoma and osteosarcoma. The therapeutic candidate comprises of modified HSV-1 that delivers gene encoding interleukin 2 (IL 2) and interleukin 12 (IL 12). It is administered through inhalational route and intratumor route in the form of solution.

Krystal Biotech overview

Krystal Biotech is a gene therapy company that develops and commercializes treatments for dermatological diseases. The company’s pipeline includes B-VEC (bercolagene telserpavec) gene therapy, against dystrophic epidermolysis bullosa (DEB), KB105 therapy, targeting autosomal recessive congenital ichthyosis (ARCI), a genetic skin disease caused due to deficiency of TGM1 gene. Krystal Biotech also investigating KB301, to treat aesthetic skin conditions, KB104, against Netherton Syndrome, KB407, for the treatment of Junctional Epidermolysis Bullosa (JEB) and KB5XX, targeting chronic skin diseases. The company utilizes the skin TARgeted Delivery (STAR-D) platform to develop treatments for skin diseases. Krystal Biotech is headquartered in Pittsburgh, Pennsylvania, the US.

For a complete picture of KB-707’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 20 February 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.