NanoFlu is a subunit vaccine commercialized by Novavax, with a leading Phase III program in Influenzavirus B Infections;Influenza A Virus, H3N2 Subtype Infections. According to Globaldata, it is involved in 7 clinical trials, of which 3 were completed, 1 is ongoing, 2 are planned, and 1 was terminated. GlobalData uses proprietary data and analytics to provide a complete picture of NanoFlu’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for NanoFlu is expected to reach an annual total of $479 mn by 2037 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
NanoFlu Overview
Nanoflu is under development for the prevention of influenza A strains including H1N1, H3N2 and influenza B virus infections and seasonal influenza. It is administered through intramuscular route. It acts by targeting hemagglutinin. The vaccine candidate is a recombinant trivalent nanoparticle influenza vaccine with matrix-M1 adjuvant (NanoFlu) developed based on recombinant protein nanoparticle technology.
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Novavax Overview
Novavax is a biotechnology company that discovers, develops and commercializes vaccines to prevent a wide range of infectious diseases. The company develops genetically-engineered vaccine candidates harnessing three-dimensional nanostructures of recombinant proteins critical to disease pathogenesis. Its pipeline products include NVX-CoV2373 for coronavirus, NanoFlu for seasonal influenza, ResVax for respiratory syncytial syndrome and vaccines indicated for the prevention of Ebola virus, Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS). It is also developing proprietary immune stimulating saponin-based adjuvants. The company operates research and manufacturing facilities in Gaithersburg, Maryland; Uppsala, Sweden; and Bohumil, Czech Republic. Novavax is headquartered in Gaithersburg, Maryland, the US.
The company reported revenues of (US Dollars) US$1,981.9 million for the fiscal year ended December 2022 (FY2022), an increase of 72.9% over FY2021. The operating loss of the company was US$644.7 million in FY2022, compared to an operating loss of US$1,686.6 million in FY2021. The net loss of the company was US$657.9 million in FY2022, compared to a net loss of US$1,743.8 million in FY2021.
For a complete picture of NanoFlu’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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