Pamiparib is a Small Molecule owned by BeiGene, and is involved in 21 clinical trials, of which 7 were completed, 12 are ongoing, and 2 are planned.
Pamiparib (BGB-290) works by inhibiting the enzymes poly (ADP-ribose) polymerase 1 and 2 (PARP-1 and PARP-2). PARP catalyses Poly(ADP-ribosyl)ation which is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contribute to the survival of injured proliferating cells. Tumor cells are more dependent on PARP. Thus the PARP serves as a target for an anticancer activity allowing tumor cells to remain as such without any repair process leading to apoptosis.
The revenue for Pamiparib is expected to reach a total of $1.4bn through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Pamiparib NPV Report.
Pamiparib is an anti-neoplastic agent. It is formulated as capsules for oral route of administration. Pamiparib is indicated for the treatment of patients with germline BRCA mutation-associated recurrent advanced ovarian, fallopian tube, or primary peritoneal cancer who have been treated with two or more lines of chemotherapy.
Pamiparib (BGB-290) is under development for the treatment of metastatic or unresectable renal cell carcinoma, advanced or metastatic adenocarcinoma of the stomach or gastro esophageal junction, relapsed or refractory solid tumors including recurrent glioblastoma multiforme (GBM), cervical cancer, bile duct cancer, peripheral nerve sheath cancer, ovarian cancer, endometrial cancer, triple negative breast cancer, metastatic HR positive and HER2 negative breast cancer, non-squamous non-small cell lung cancer, squamous non-small cell lung cancer, head and neck squamous cell carcinoma, esophageal cancer, gastric cancer, leiomyosarcoma, undifferentiated pleomorphic sarcoma, dedifferentiated liposarcoma, myxofibrosarcoma, primary peritoneal cancer, fallopian cancer, metastatic castration-resistant prostate cancer (mCRPC), high-grade glioma, low-grade glioma, colorectal cancer, metastatic adenocarcinoma of the pancreas, muscle invasive bladder cancer, transitional cell cancer(urothelial cell cancer), small-cell lung cancer and pancreatic cancer. The drug candidate is administered orally. It targets the enzymes poly (ADP-ribose) polymerase 1 and 2 (PARP-1 and PARP-2).
BeiGene is a biotechnology company. It is specialized in the development and commercialization of immuno-oncology medicines to treat cancers. The company offers BRUKINSA, a BTK (Bruton’s tyrosine kinase) inhibitor against mantle cell lymphoma (MCL). BeiGene is investigating Zanubrutinib (BGB-3111), a small molecule inhibitor of BTK to treat B cell malignancies; Tislelizumab (BGB-A317), a monoclonal antibody targeting solid tumors and hematologic cancer; and Pamiparib (BGB-290) against solid tumor malignancies. It seeks to work in partnership with academia, biotechnology and pharmaceutical companies to develop treatments for cancer patients. The company has operations in the US, Australia, Germany, Spain Switzerland, and Italy. BeiGene is headquartered in Beijing, China.
The company reported revenues of (US Dollars) US$1,176.3 million for the fiscal year ended December 2021 (FY2021), compared to a revenue of US$308.9 million in FY2020. The operating loss of the company was US$1,438.7 million in FY2021, compared to an operating loss of US$1,657.7 million in FY2020. The net loss of the company was US$1,413.4 million in FY2021, compared to a net loss of US$1,596.9 million in FY2020. The company reported revenues of US$387.6 million for the third quarter ended September 2022, a decrease of 40.2% over the previous quarter.
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