Rucaparib camsylate is under clinical development by Clovis Oncology and currently in Phase II for Hormone-Sensitive Prostate Cancer. According to GlobalData, Phase II drugs for Hormone-Sensitive Prostate Cancer have a 74% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Rucaparib camsylate’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Rucaparib camsylate overview
Rucaparib camsylate (Rubraca) is an anti neoplastic agent. It is formulated as film coated tablets for oral route of administration. Rucaparib camsylate is indicated as a monotherapy treatment in patients with deleterious BRCA mutation (germline and/or somatic) associated advanced ovarian cancer who have been treated with two or more chemotherapies, and for the maintenance treatment of recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy. It acts by targeting PARP (poly (ADP-ribose)polymerase).
It is under development for treatment in patients with recurrent solid tumors associated with a deleterious mutation in homologous-recombination deficient (HRD) adenocarcinoma of the cervix and adenocarcinoma of the endometrium, metastatic pancreatic cancer, pancreatic ductal adenocarcinoma, leiomyosarcoma, urothelial carcinoma, triple negative breast cancer, metastatic breast cancer, non-squamous non-small cell lung cancer, fallopian tube cancer, peritoneal cancer, epithelial ovarian cancer, metastatic biliary tract cancer, hormone-sensitive prostate cancer, malignant mesothelioma, metastatic hormone refractory (Castration Resistant, Androgen-Independent) prostate cancer, non-metastatic triple negative breast cancer, non-small cell lung cancer, gastro-esophageal junction adenocarcinoma and clear cell renal cell carcinoma. It was also under development for metastatic urothelial cancer (third line therapy), high-grade serous ovarian cancer, or BRCA 1/2 mutated breast cancer, and other solid tumor with BRCA 1/2 or related gene mutation metastatic prostate cancer and esophageal cancer.
Clovis Oncology overview
Clovis Oncology (Clovis) is a biopharmaceutical company that develops and commercializes anti-cancer agents in the US and internationally. The company’s lead product includes Rubraca, an oral small molecule inhibitor of poly ADP-ribose polymerase used for the treatment of adults with BRCA mutation-associated metastatic castrate-resistant prostate cancer. Its major pipeline products include Rucaparib, which is intended for the treatment of ovarian cancer, prostate cancer, gastric cancer, and solid tumors with mutations in homologous recombination repair genes. The company’s preclinical candidate, FAP-2286 is a peptide-targeted radionuclide therapy and imaging agent intended for the treatment of cancer. It operates in California, the US; Cambridge, the UK; and Milan, Italy; among others. Clovis is headquartered in Boulder, Colorado, the US.
For a complete picture of Rucaparib camsylate’s drug-specific PTSR and LoA scores, buy the report here.