Rucaparib camsylate is under clinical development by Clovis Oncology and currently in the Phase II in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Rucaparib camsylate’s likelihood of approval (LoA) and phase transition for Metastatic Biliary Tract Cancer took place on 05 Sep 2022, which decreased the likelihood that the drug progresses to the next phase in its clinical pathway.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Rucaparib camsylate Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Rucaparib camsylate overview

Rucaparib camsylate (Rubraca) is an anti neoplastic agent. It is formulated as film coated tablets for oral route of administration. Rucaparib camsylate is indicated as a monotherapy treatment in patients with deleterious BRCA mutation (germline and/or somatic) associated advanced ovarian cancer who have been treated with two or more chemotherapies, and for the maintenance treatment of recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy. It acts by targeting PARP (poly (ADP-ribose)polymerase).

It is under development for treatment in patients with recurrent solid tumors associated with a deleterious mutation in homologous-recombination deficient (HRD) adenocarcinoma of the cervix and adenocarcinoma of the endometrium, metastatic pancreatic cancer, pancreatic ductal adenocarcinoma, leiomyosarcoma, urothelial carcinoma, triple negative breast cancer, metastatic breast cancer, non-squamous non-small cell lung cancer, fallopian tube cancer, peritoneal cancer, epithelial ovarian cancer, metastatic biliary tract cancer, hormone-sensitive prostate cancer, malignant mesothelioma, metastatic hormone refractory (Castration Resistant, Androgen-Independent) prostate cancer, non-metastatic triple negative breast cancer, non-small cell lung cancer, gastro-esophageal junction adenocarcinoma and clear cell renal cell carcinoma. It was also under development for metastatic urothelial cancer (third line therapy), high-grade serous ovarian cancer, or BRCA 1/2 mutated breast cancer, and other solid tumor with BRCA 1/2 or related gene mutation metastatic prostate cancer and esophageal cancer.

Clovis Oncology overview

Clovis Oncology (Clovis) is a biopharmaceutical company that develops and commercializes anti-cancer agents in the US and internationally. The company’s lead product includes Rubraca, an oral small molecule inhibitor of poly ADP-ribose polymerase used for the treatment of adults with BRCA mutation-associated metastatic castrate-resistant prostate cancer. Its major pipeline products include Rucaparib, which is intended for the treatment of ovarian cancer, prostate cancer, gastric cancer, and solid tumors with mutations in homologous recombination repair genes. The company’s preclinical candidate, FAP-2286 is a peptide-targeted radionuclide therapy and imaging agent intended for the treatment of cancer. It operates in California, the US; Cambridge, the UK; and Milan, Italy; among others. Clovis is headquartered in Boulder, Colorado, the US.

Quick View Rucaparib camsylate LOA Data

Report Segments
  • Innovator (NME)
Drug Name
  • Rucaparib camsylate
Administration Pathway
  • Oral
Therapeutic Areas
  • Oncology
Key Developers
Highest Development Stage
  • Marketed

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.