Sebetralstat is under clinical development by Kalvista Pharmaceuticals and currently in Phase III for Hereditary Angioedema (HAE) (C1 Esterase Inhibitor [C1-INH] Deficiency). According to GlobalData, Phase III drugs for Hereditary Angioedema (HAE) (C1 Esterase Inhibitor [C1-INH] Deficiency) have a 78% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData’s report assesses how Sebetralstat’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Sebetralstat overview
Sebetralstat (KVD-900) is under development for the treatment of hereditary angioedema. The drug candidate is administered through oral route in the form of the tablet. It acts by targeting plasma kallikrein.
Kalvista Pharmaceuticals overview
Kalvista Pharmaceuticals, Inc. is a pharmaceutical company that is into the discovery, development, and commercialization of oral, small-molecule protease inhibitors for diseases with significant unmet needs. The company’s product pipeline includes sebetralstat, oral factor Xlla and KVD001. Its pipeline candidates treat hereditary angioedema, prophylaxis in hereditary angioedema, thrombosis inflammation and diabetic macular edema. Kalvista is also progressing additional oral candidates toward regulatory preclinical studies. The company has its operations in the US and the UK. Kalvista is headquartered in Cambridge, Massachusetts, the US.
For a complete picture of Sebetralstat’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
