SL-172154 is a fusion protein commercialized by Shattuck Labs, with a leading Phase I program in Metastatic Ovarian Cancer. According to Globaldata, it is involved in 4 clinical trials, of which 1 was completed, 2 are ongoing, and 1 was terminated. GlobalData uses proprietary data and analytics to provide a complete picture of SL-172154’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

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The revenue for SL-172154 is expected to reach an annual total of $20 mn by 2039 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

SL-172154 Overview

SL-172154 is under development for the treatment of advanced or metastatic ovarian cancer, epithelial ovarian cancer, primary peritoneal cancer, fallopian tube cancer, acute myeloid leukemia (AML) and higher-risk myelodysplastic syndromes (HR-MDS). The drug candidates are based on Agonist Redirected Checkpoints (ARC) technology. The drug candidate is a two-sided human fusion protein incorporating the ECDs of SIRPα and CD40L, adjoined by a central Fc domain termed as SIRPα-Fc-CD40L. It is administered through intravenous route.

It was under development for the treatment of recurrent head and neck cancer squamous cell carcinoma, cutaneous squamous cell carcinoma, skin cancer, colon cancer and hematological malignancies. 

Shattuck Labs Overview

Shattuck Labs (Shattuck) is a biotechnology company that develops bi-functional fusion proteins for the treatment of cancer and autoimmune disease. The company develops products using its proprietary agonist redirected checkpoint (ARC) platform and gamma delta T Cell engager (GADLEN) platform. Shattuck’s lead products include, SL-172154 (SIRPa-Fc-CD40L) developed for the treatment of ovarian cancer, cutaneous squamous-cell carcinoma (cSCC) and head and neck squamous cell carcinoma (HNSCC) and SL-279252 (PD1-Fc-OX40L) for advanced solid tumors and lymphoma. The company is also evaluating drugs targeting oncology, advanced solid tumors and autoimmune diseases. It operates a research and development office in Durham, North Carolina. Shattuck is headquartered in Austin, Texas, the United States.
The company reported revenues of (US Dollars) US$0.7 million for the fiscal year ended December 2022 (FY2022), a decrease of 97.8% over FY2021. The operating loss of the company was US$103.3 million in FY2022, compared to an operating loss of US$45.3 million in FY2021. The net loss of the company was US$101.9 million in FY2022, compared to a net loss of US$45 million in FY2021. The company reported revenues of US$0.7 million for the third quarter ended September 2023, compared to a revenue of US$0.2 million the previous quarter.

For a complete picture of SL-172154’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 20 May 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.