SLN-124 is under clinical development by Silence Therapeutics and currently in Phase I for Alpha Thalassaemia. According to GlobalData, Phase I drugs for Alpha Thalassaemia does not have sufficient historical data to build an indication benchmark PTSR for Phase I. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the SLN-124 LoA Report. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

SLN-124 overview

SLN-124 is under development for the treatment of hereditary hemochromatosis, alpha/beta thalassemia, polycythaemia vera. The therapeutic candidate is composed of the oligonucleotide conjugated with N-acetylgalactosamine (GalNAc). It is administered through subcutaneous route. It is developed based on GalNAc-siRNA technology and mRNAi GOLD platform . It acts by tageting transmembrane protease serine 6 (TMPRSS6). 
It was also under development for myelodysplastic syndrome.

Silence Therapeutics overview

Silence Therapeutics is a developer of therapeutics that channels gene silencing to cure life-threatening diseases. The company’s pipeline products include SLN124 and SLN360. Its SLN360 is developed for the treatment of cardiovascular disease with high Lp(a) in risk of heart disease and heart stroke, and SLN124 for e-Thalassaemia and myelodysplastic syndrome. Silence Therapeutics also provides RNA interfaces that include short interfering RNA (siRNA) and messenger RNAs (mRNA). The company collaborates with pharmaceutical, biotechnology companies and academic research institutions. It operates in Germany, the US and the UK. Silence Therapeutics is headquartered in London, England, the UK.

For a complete picture of SLN-124’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 20 February 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.