TN-401 is under clinical development by Tenaya Therapeutics and currently in Phase I for Cardiomyopathy. According to GlobalData, Phase I drugs for Cardiomyopathy have an 86% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how TN-401’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

TN-401 overview

TN-401 is under development for the treatment of genetic arrhythmogenic right ventricular cardiomyopathy. It comprises adeno associated virus (AAV9) delivering the gene encoding plakophilin 2 (PKP2). The drug candidate is administered through intravenous route.

Tenaya Therapeutics overview

Tenaya Therapeutics is a biopharmaceutical company that develops novel therapies to treat heart diseases. The company utilizes its cellular regeneration, gene therapy, and precision medicine product platforms for drug development. Its product pipeline includes TN-201 to treat hypertrophic cardiomyopathy; TN-401 for treatment of cardiomyopathy; TN-301 targeting diastolic heart failure and dilated cardiomyopathy; and DWORF to treat congestive heart failure. Tenaya Therapeutics is also developing other drug candidates to treat dilated cardiomyopathy, heart failure, heart failure with preserved ejection fraction (HFrEF), hypertrophic cardiomyopathy, and genetic and idiopathic cardiomyopathies. The company works in collaboration with Gladstone Institutes and University of Texas Southwestern Medical Center. Tenaya Therapeutics is headquartered in South San Francisco, California, the US.

For a complete picture of TN-401’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 20 May 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.