TYRA-300 is a small molecule commercialized by Tyra Biosciences, with a leading Phase II program in Metastatic Transitional (Urothelial) Tract Cancer. According to Globaldata, it is involved in 2 clinical trials, which are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of TYRA-300’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for TYRA-300 is expected to reach an annual total of $131 mn by 2035 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Tyra-300 is under development for the treatment of metastatic urothelial carcinoma of the bladder and urinary tract, solid tumors and achondroplasia. The drug candidate acts by targeting fibroblast growth factor (FGF) receptor 3. It is being developed based on SNAP platform. It is administered by oral route.
Tyra Biosciences Overview
Tyra Biosciences (Tyra) is a precision oncology company that design and develop cancer drugs. It is investigating Tyra-300, an FGFR3 (fibroblast growth factor receptor 3) inhibitor targeting bladder and solid tumors. The company evaluates FGFR2 small molecule inhibitor for the treatment of bile duct and solid tumors; FGFR3 (ACH) program against achondroplasia; an RET-specific inhibitor for lung and thyroid cancer; and FGFR4-specific inhibitor liver and solid tumors. It utilizes SNAP, a proprietary in-house discovery engine to discover and develop molecular structures for cancer. Tyra is headquartered in Carlsbad, California, the US.
The operating loss of the company was US$58.9 million in FY2022, compared to an operating loss of US$26.3 million in FY2021. The net loss of the company was US$55.3 million in FY2022, compared to a net loss of US$26.3 million in FY2021.
For a complete picture of TYRA-300’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.