Volixibat potassium is under clinical development by Mirum Pharmaceuticals and currently in Phase II for Primary Biliary Cholangitis (Primary Biliary Cirrhosis). According to GlobalData, Phase II drugs for Primary Biliary Cholangitis (Primary Biliary Cirrhosis) have a 42% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Volixibat potassium’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Volixibat potassium overview
Volixibat potassium (SHP-626, LUM-002) is under development for primary sclerosing cholangitis and its associated pruritus and primary biliary cholangitis. It is administered through the oral route as a capsule. The drug candidate selectively targets apical sodium-dependent bile acid transporter (ASBT). The human apical sodium-dependent bile acid transporter (SLC10A2) belongs to the solute carrier family (SLC) of transporters and is an important carrier protein expressed in the small intestine.
It was also under development for the treatment of nonalcoholic steatohepatitis (NASH) by Shire, adult cholestasis (intrahepatic cholestasis of pregnancy), and Type 2 diabetes.
Mirum Pharmaceuticals overview
Mirum Pharmaceuticals is biopharmaceutical company that develops a pipeline of novel therapies for debilitating liver diseases. The company’s pipeline products include Maralixabat, minimally absorbed, orally administered investigational drug and Volixibat, a minimally absorbed agent designed to selectively inhibit ASBT. It develops products to treat rare cholestatic liver diseases that include progressive familial intrahepatic cholestasis (PFIC), alagille syndrome (ALGS), biliary atresia (BA), primary sclerosing cholangitis (PSC) and intrahepatic cholestasis of pregnancy (ICP). Mirum Pharmaceuticals is headquartered in Foster City, California, the US.
For a complete picture of Volixibat potassium’s drug-specific PTSR and LoA scores, buy the report here.