Vor BioPharma has been granted a patent for genetically engineered hematopoietic cells with edited genes for cell-surface proteins, used in treating hematopoietic malignancies like acute myeloid leukemia. The method involves administering these cells along with agents targeting specific proteins. GlobalData’s report on Vor BioPharma gives a 360-degree view of the company including its patenting strategy. Buy the report here.
According to GlobalData’s company profile on Vor BioPharma, was a key innovation area identified from patents.
Genetically engineered hematopoietic cells for treating acute myeloid leukemia
A recently granted patent (Publication Number: US11903973B2) outlines a method for treating hematopoietic malignancies, specifically acute myeloid leukemia (AML). The method involves administering genetically engineered hematopoietic cells (HCs) to a subject, where these cells are modified to have reduced or eliminated expression of CD33 and CD123 genes. Additionally, a therapeutically effective amount of an agent with anti-CD33 or anti-CD123 binding domains is also administered to the subject. The genetically engineered HCs are prepared using a CRISPR system and are capable of normal differentiation, expansion, and engraftment, making them a promising treatment option for AML.
Furthermore, the patent also describes a method for preparing a population of genetically engineered HCs by modifying the CD33 and CD123 genes in HCs obtained from a human subject. The modified HCs exhibit reduced or no binding to the anti-CD33 and anti-CD123 agents, ensuring targeted treatment of AML. The genetically engineered HCs retain their normal differentiation capacity and are capable of engraftment, making them a viable option for treating hematopoietic malignancies. The use of CRISPR technology in the genetic modification process enhances the precision and efficiency of the treatment, offering a potential breakthrough in the field of AML therapy.
To know more about GlobalData’s detailed insights on Vor BioPharma, buy the report here.
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