WuXi AppTec has patented a process for preparing a dichloroacetic acid composition with less than 1000 ppm glyoxylic acid. The method involves mixing a dichloroacetic acid material with a glyoxylic acid capture reagent to achieve the desired purity level. GlobalData’s report on WuXi AppTec gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on WuXi AppTec, AI-assisted drug screening was a key innovation area identified from patents. WuXi AppTec's grant share as of January 2024 was 31%. Grant share is based on the ratio of number of grants to total number of patents.
Process for preparing dichloroacetic acid composition with low impurity
A recently granted patent (Publication Number: US11873318B2) discloses a process for preparing a dichloroacetic acid composition with less than 1000 ppm glyoxylic acid. The method involves mixing a dichloroacetic acid material containing more than 1000 ppm glyoxylic acid with a glyoxylic acid capture reagent to achieve the desired composition. The capture reagent can be selected from various compounds such as amino acids, chemicals with bifunctional or multifunctional groups, hydroxylamine compounds, reductants, or their mixtures.
Furthermore, the patent describes a method for synthesizing oligonucleotides using a substantially pure dichloroacetic acid with less than 50 ppm glyoxylic acid. This involves mixing the pure dichloroacetic acid with a protected oligonucleotide under specific conditions to remove the acid labile protecting group, resulting in a deprotected oligonucleotide. The process includes steps to reduce the glyoxylic acid content in the starting dichloroacetic acid composition to less than 50 ppm, ensuring the purity of the final product. The protected oligonucleotide can have a 5'-hydroxyl group protected with an acid labile protecting group, such as a trityl group, and may be bound to a solid support for further applications. The patent also outlines a method for analyzing and reducing the glyoxylic acid level in the starting dichloroacetic acid composition to less than 50 ppm by utilizing a glyoxylic acid capture agent, followed by distillation of the dichloroacetic acid to obtain the desired composition.
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