SanBio has been granted a patent for cell preparations that can modulate peripheral immune functions. The patent includes a method for suppressing TH1 helper T cell function in a subject by administering cells obtained through a specific process involving mesenchymal stem cells and Notch intracellular domain sequences. GlobalData’s report on SanBio gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on SanBio, NSAID cancer drugs was a key innovation area identified from patents. SanBio's grant share as of February 2024 was 59%. Grant share is based on the ratio of number of grants to total number of patents.
Cell preparations for modulating immune functions by suppressing th1 cells
A recently granted patent (Publication Number: US11903972B2) discloses a method for suppressing the function of TH1 and TH2 helper T cells in a subject by administering cells obtained through a specific process. The method involves providing a culture of mesenchymal stem cells, contacting the cell culture with a polynucleotide encoding a Notch intracellular domain (NICD), selecting cells containing the polynucleotide, and further culturing them without selection for the polynucleotide. The functions targeted for suppression in TH1 cells include activation of macrophages, cytotoxic T-cells, B cells, secretion of interferon gamma (IFN-?), and tumor necrosis factor alpha (TNF-a.
In addition to suppressing TH1 cells, the patent also covers a method for suppressing the function of TH2 helper T cells in a subject using cells obtained through a similar process involving mesenchymal stem cells and a polynucleotide encoding NICD. The functions targeted for suppression in TH2 cells include activation of antibody production by B cells, secretion of interleukin 4 (IL-4), and interleukin 10 (IL-10). This innovative method offers a potential therapeutic approach for modulating immune responses by selectively suppressing specific T cell functions in subjects.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
