Rising healthcare expenditure, growing geriatric population, increasing incidence of chronic diseases, patent expiration of blockbuster drugs, and increased consumption of generic drugs have created opportunities for API chemical companies, which can provide their expertise to pharmaceutical companies.

Despite the growing popularity of API biologics, API chemicals remain much in demand. The various manufacturing services for APIs and intermediates offered by contract manufacturing companies range from clinical-stage development to commercial launch.

Finding the top API chemical companies in contract manufacturing

Pharmaceutical Technology has listed the leading API chemical companies in contract manufacturing based on its intel, insights, and decades of experience in the sector. The list includes companies that provide various products and services including, but not limited to:

  • GMP manufacturing
  • Industrial-scale manufacturing of complex molecules
  • Analytical services and regulatory support
  • Manufacturing to support clinical trials, and
  • Tech transfer and scale-up management

The information contained within the download document is intended for pharmaceutical manufacturers, pharmaceutical executives, process engineers, and any other individual involved in API chemical procurement and manufacturing.

The document contains detailed information on the manufacturers and their services, alongside contact details to aid your hiring decision.

Related Buyer’s Guides which cover an extensive range of pharmaceutical equipment manufacturers, solutions providers and technology can also be found here.

Technologies in API chemical manufacturing

API chemical companies are investing in the latest technologies and processes such as lyophilisation, particle engineering, polymorph screening and solid-state chemistry that enable the production of specialised APIs, high-potent APIs (HPAPIs), and intermediates.

The key purification technologies used by chemical companies include catalytic organic synthesis, continuous flow processing, cryogenic chemistry, fermentation, amino acid chemistry, chromatography, fractional crystallisation, solvent extraction, nano-milling, and chiral synthesis.

Moving API production closer to the operating location is one of the trends that is emerging in the sector due to the supply chain constraints created during the Covid-19 pandemic. API chemical companies that have manufacturing facilities closer to pharmaceutical companies are likely to benefit more amid this trend.

Furthermore, the rising energy costs, raw material costs and demand for sustainable practices will require contract manufacturing organisations to demonstrate how they can provide services more efficiently to pharmaceutical companies.