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December 16, 2021updated 11 Jan 2022 3:12pm

Cleanrooms and Cleanroom Flooring

By Elli Karampela

Pharmaceutical manufacturing requires a high level of cleanliness and sterile environments for production. Cleanrooms provide a controlled environment that protects pharmaceutical products from contamination and pollutants such as dust, airborne microbes and aerosol particles.

The flooring of cleanrooms further ensures that they comply with the International Organization for Standardization (ISO) and Good Manufacturing Practice (GMP) standards while reducing the risk of contamination from volatile particles.

Top pharmaceutical cleanroom flooring suppliers and cleanroom contractors

Pharmaceutical Technology has listed the leading contractors and suppliers of cleanrooms and cleanroom flooring based on its intel, insights, and decades-long experience in the pharmaceutical sector. The list includes cleanroom design and installation contractors, cleanroom classification and maintenance providers, and modular and mobile cleanroom suppliers.

There are also separate lists for providers of cleanroom equipment and supplies, such as glove boxes and isolators, suits, protective goggles, furniture and hand wash systems, and providers of contamination control solutions and pharmaceutical cleanroom flooring.

The information contained within the download document is designed for cleanroom designers and engineers, pharmaceutical production managers and supervisors, quality control executives, cleanroom operators, production specialists, bioprocessing designers, laboratory analysts, and heating, ventilation and air conditioning (HVAC) engineers.

The download contains detailed information on suppliers and their product lines, as well as contact details to aid in purchasing decisions.

Cleanroom pharmaceutical manufacturing essentials

Cleanrooms need to be maintained at the highest levels of cleanliness to ensure a pollutant-free environment. Some of the basic essentials that are needed to ensure a sterile environment include:

  • Protective clothing, including gowns, gloves, and suits
  • Cleanroom furniture designed to remain dust and particle-free
  • Cleanroom flooring that is non-shedding and easy-to-clean
  • Air showers and handwashing systems
  • Cleanroom high-efficiency particulate air (HEPA) and ultra-low particulate air (ULPA) filters
  • Ceiling tiles
  • Modular partitions and curtains
  • Air conditioning units
  • Pass-through cabinets and talk-through windows
  • Particle counters
  • Humidity and temperature control equipment

Selecting the right pharmaceutical cleanroom flooring

Most of the contamination present in a cleanroom is found on the floor, due to the downward flow of pollutants and dust particles. Choosing the right pharmaceutical cleanroom flooring is, therefore, essential to reducing the risk of contamination and complying with GMP standards for cleanroom pharmaceutical manufacturing.

The flooring should be resistant to chemicals and solvents, otherwise caustic solutions used for washing the cleanroom can cause damage. The flooring should also be free from joints and cracks, which can allow bacterial growth and the accumulation of particulate matter. The finishing and texture of the flooring should be selected to reduce slipperiness, increase traction, and ensure easy cleaning.

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