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  1. Clinical Trials Analysis
October 12, 2021

Depression accounts for 7.6% share of global Central Nervous System clinical trial activity in 2020

Depression accounted for a 7.6% share of the global clinical trials within the Central Nervous System therapy area in 2020, registering a decrease of 0.1% when compared with the last ten-year average of 7.7% share, according to GlobalData.

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Non-industry sponsored trials outnumber industry sponsored trials for Depression

Industry sponsored trials held a 38.5% share of all the clinical trials for Depression indication in 2020, registering an increase of 4.6% when compared with the ten-year average of 33.9%. Non-industry sponsored trials accounted for a 61.5% share in 2020, marking a decrease of 4.6% over the ten-year average of 66.1%.

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Top regions of industry sponsored Depression trials

Asia-Pacific was the top region for industry sponsored Depression trials, accounting for a 65.0% share in 2020, when compared with the five-year average of 44.5% and ten-year average of 39.3%.

Europe was at the second position with a 26.0% share in 2020, over the five-year average of 33.6% and ten-year average of 35.7%, followed by North America with a 24.0% share in 2020, as against five-year and ten-year averages of 38.8% and 45.2% respectively.

South and Central America stood fourth with a 5.0% share in 2020, compared with the five-year average of 4.5% and ten-year average of 5.9%, followed by Middle East and Africa with a 2.0% share in 2020, over five-year and ten-year averages of 5.5% and 4.7% respectively.

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China was the top country for industry sponsored Depression trials, accounting for a 44.0% share in 2020, as against the five-year average of 22.6% and ten-year average of 13.6%.

The US held a 22.0% share in 2020, over the five-year average of 37.4% and ten-year average of 43.6%, followed by Russia with a 10.0% share in 2020, compared with the five-year and ten-year averages of 11.3% and 12.4% respectively.

Czech Republic held a 7.0% share in 2020, as against the five-year average of 3.1% and ten-year average of 3.9%.

India held a 7.0% share in 2020, over the five-year and ten-year averages of 3.1% and 6.8% respectively.

Top regions of non-industry sponsored Depression trials

Asia-Pacific was the top region for non-industry sponsored Depression trials, accounting for a 51.2% share in 2020 when compared with the five-year average of 35.2% and ten-year average of 32.0%.

Middle East and Africa was at the second position with a 20.3% share in 2020, over the five-year and ten-year averages of 20.6% and 18.8% respectively, followed by North America with a 16.3% share in 2020, as against the five-year average of 29.4% and ten-year average of 33.2%.

Europe stood at the fourth position with an 11.6% share in 2020, compared with the five-year average of 13.8% and ten-year average of 15.5%, followed by South and Central America with a 0.6% share in 2020, over the five-year and ten-year averages of 2.1% and 2.2% respectively.

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China was the top country for non-industry sponsored Depression trials, accounting for a 36.0% share in 2020, as against the five-year average of 17.2% and ten-year average of 12.6%.

Iran held an 18.0% share in 2020, over the five-year average of 18.8% and ten-year average of 16.7%, followed by US with a 15.7% share, compared with the five-year and ten-year averages of 25.5% and 28.2% respectively.

India held an 8.1% share in 2020, as against the five-year average of 5.4% and ten-year average of 4.1%.

Australia held a 3.5% share in 2020, over the five-year average of 2.8% and ten-year average of 3.5%.

Phase I trials lead industry sponsored clinical trials for Depression in 2020

Phase I trials held a 50.0% share of industry sponsored clinical trials for Depression in 2020, over the five-year average of 51.8% and ten-year average of 47.7%.

Phase II trials held an 18.8% share in 2020, as against the five-year average of 18.6% and ten-year average of 16.7%. Phase III trials held a 17.9% share in 2020, compared with the five-year and ten-year averages of 20.2% and 24.6% respectively.

Phase IV trials held a 13.4% share in 2020, over the five-year average of 9.4% and ten-year average of 11.0%.

Phase II trials lead non-industry sponsored clinical trials for Depression in 2020

Phase II trials held a 33.0% share of non-industry sponsored clinical trials for Depression in 2020, over the five-year average of 46.2% and ten-year average of 44.5%.

Phase IV trials held a 27.4% share in 2020, as against the five-year average of 23.7% and ten-year average of 28.2%. Phase III trials held a 26.3% share, compared with the five-year and ten-year averages of 18.9% and 17.4% respectively.

Phase I trials held a 13.4% share in 2020, over the five-year average of 11.2% and ten-year average of 9.9%.

Methodology:
The clinical trials data used for the analyses were extracted from the Clinical Trials Database of GlobalData’s Pharma Intelligence Center. Clinical Trials are sourced from numerous government, non-government and company clinical trial registries worldwide alongside clinical research publications, scientific conferences, company websites, SEC filings and more. The information is gathered by a combination of automation and secondary research to ensure accuracy and validity. A small number of Phase 0, Phase I/II, Phase II/III, and Phase III/IV trials were combined with Phase I, Phase II, Phase III, and Phase IV trials, respectively.

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