Actinium Pharmaceuticals has patented a method using radiolabeled anti-CD45 antibodies to deplete hematopoietic stem cells in human subjects for genetically edited cell therapy. The method targets non-cancerous disorders like hemoglobinopathy, immunodeficiency, or viral infections, reducing stem cell populations by specified percentages. GlobalData’s report on Actinium Pharmaceuticals gives a 360-degree view of the company including its patenting strategy. Buy the report here.
According to GlobalData’s company profile on Actinium Pharmaceuticals, Antibody drug conjugates(ADC) cancer therapy was a key innovation area identified from patents. Actinium Pharmaceuticals's grant share as of February 2024 was 28%. Grant share is based on the ratio of number of grants to total number of patents.
A recently granted patent (Publication Number: US11912780B2) outlines a method for depleting hematopoietic stem cells in human subjects to prepare for genetically edited hematopoietic stem cell therapy. The method involves administering a radiolabeled anti-CD45 antibody, specifically radiolabeled BC8 with 131I or 225Ac, to individuals with non-cancerous disorders such as hemoglobinopathies, congenital immunodeficiencies, or viral infections. The depletion of hematopoietic stem cells aims to reduce their population by varying percentages, ranging from 10% to 99%. The effective amount of the radiolabeled BC8, whether 131I-BC8 or 225Ac-BC8, is crucial and administered as a single dose.
Furthermore, the patent details the treatment of non-cancerous disorders like sickle cell disease (SCD) or severe combined immunodeficiency disease (SCID) through genetically edited hematopoietic stem cell therapy post-depletion of stem cells. The genetically edited therapy can involve specific genes like the common gamma chain (?c) gene or adenosine deaminase (ADA) gene. The radiolabeled BC8, whether 131I-BC8 or 225Ac-BC8, is administered in varying effective amounts based on subject weight, ranging from 0.1 µCi/kg to 5.0 µCi/kg. The patent also includes an article of manufacture comprising the radiolabeled anti-CD45 antibody and instructions for administration to achieve the desired depletion of hematopoietic stem cells, emphasizing the importance of precise dosages for optimal therapeutic outcomes.
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