Amgen. has filed a patent for a process to prepare compound A, involving specific chemical reactions. The process includes mixing various compounds in specific sequences to obtain the desired product. This patent also covers the synthesis of AMG 510 using Compound A. GlobalData’s report on Amgen gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Amgen, NSAID cancer drugs was a key innovation area identified from patents. Amgen's grant share as of January 2024 was 42%. Grant share is based on the ratio of number of grants to total number of patents.
The patent application (Publication Number: US20240025896A1) describes a process for preparing Compound A through a series of steps involving the addition of Compound B, a first base, and a reactive compound to an organic solvent solution. The process includes specific temperature ranges and molar equivalents for the components involved, such as Compound B, the first base, and the reactive compound. Additionally, the process involves the use of specific bases, such as N,N-diisopropylethylamine, and organic solvents like acetonitrile. The method also includes the addition of a second base, such as 1,5,7-triazabicyclo(4.4.0)dec-5-ene (TBD) or 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), in specific molar equivalents based on Compound B.
Furthermore, the process includes steps for crystallizing Compound A from the product mixture by adding an aqueous solution of an acid, with phosphoric acid being a specific example. The application also mentions the isolation of the crystallized Compound A by filtration and emphasizes that certain compounds like Compound C or Compound E are not isolated before subsequent reactions. The patent application provides detailed and specific instructions for the preparation of Compound A, highlighting the importance of precise measurements, temperatures, and reagents to achieve the desired outcome efficiently and effectively.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
