Ardelyx has been granted a patent for a compound that inhibits the enzyme 11-HSD2, useful in treating hyperkalemia by preventing cortisol oxidation. The compound allows cortisol to occupy the mineralocorticoid receptor, stimulating potassium excretion. GlobalData’s report on Ardelyx gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Ardelyx, Peptide pharmacophores was a key innovation area identified from patents. Ardelyx's grant share as of February 2024 was 38%. Grant share is based on the ratio of number of grants to total number of patents.
Compound inhibiting enzyme 11-hsd2 for treating hyperkalemia
The granted patent (Publication Number: US11858959B2) discloses a compound of formula I or its salt, along with specific structural variations denoted as Ia-Io. The compound, when V is —C(O)—O— and R2 is H, is claimed to be effective. Additionally, the patent covers variations where R1 can be methyl, ethyl, or isopropyl, and X and L are both bonds. The compound is further specified with different substituents on R3, R4, and R6, including alkyl, carbocycle, or heterocycle groups.
Furthermore, the patent includes methods for inhibiting the conversion of cortisol to cortisone by 11ß-HSD2 using the compound described in the claims. It also outlines methods for treating diseases or conditions related to this conversion in mammals, promoting potassium ion secretion into the colonic lumen, and treating hyperkalemia. The patent extends to pharmaceutical compositions containing the compound and a pharmaceutically acceptable carrier, diluent, or excipient, emphasizing its potential applications in various medical treatments and interventions.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
