Axatilimab is a monoclonal antibody commercialized by Incyte, with a leading Pre-Registration program in Graft Versus Host Disease (GVHD). According to Globaldata, it is involved in 16 clinical trials, of which 4 were completed, 5 are ongoing, 5 are planned, and 2 were terminated. GlobalData uses proprietary data and analytics to provide a complete picture of Axatilimab’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

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The revenue for Axatilimab is expected to reach an annual total of $305 mn by 2036 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

Axatilimab Overview

Axatilimab (SNDX-6352) is under development for the treatment of graft versus host disease, solid tumours including intrahepatic cholangiocarcinoma, relapsed and refractory Hodgkin Lymphoma and idiopathic pulmonary fibrosis. It is administered intravenously as solution for infusion. The drug candidate is a humanized IgG4 monoclonal antibody targeting colony stimulating factor 1 receptor (CSF1R). It was under development for Coronavirus disease 2019 (COVID-19).

Incyte Overview

Incyte is a biopharmaceutical company, which discovers, develops and commercializes proprietary cancer therapeutics. The company’s lead product, Jakafi (ruxolitinib) is marketed in the US for the treatment of patients with high-risk myelofibrosis; and polycythemia vera who are intolerant to hydroxyurea. The company distributes Jakafi through a network of specialty pharmacy providers and wholesalers. In collaboration with Incyte, Novartis International Pharmaceutical Ltd (Novartis) develops and commercializes ruxolitinib outside the US for hematologic and cancer indications under the name Jakavi. The company’s pipeline portfolio encompasses drugs for the treatment of lung cancer, graft versus host disease, b-cell malignancies, solid tumors, non-small cell lung cancer, glioblastoma, liver cancer, and advanced malignancies. Incyte is headquartered in Wilmington, Delaware, the US.
The company reported revenues of (US Dollars) US$3,695.7 million for the fiscal year ended December 2023 (FY2023), an increase of 8.9% over FY2022. In FY2023, the company’s operating margin was 16.8%, compared to an operating margin of 17.1% in FY2022. In FY2023, the company recorded a net margin of 16.2%, compared to a net margin of 10% in FY2022.

For a complete picture of Axatilimab’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 20 May 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.