Axsome Therapeutics has been granted a patent for a method of treating narcolepsy with cataplexy using reboxetine. The method involves administering 8-10 mg of reboxetine daily for at least two weeks to reduce daytime sleepiness in individuals experiencing frequent cataplexy attacks. GlobalData’s report on Axsome Therapeutics gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Axsome Therapeutics, Antibody-conjugate nanoparticles was a key innovation area identified from patents. Axsome Therapeutics's grant share as of January 2024 was 43%. Grant share is based on the ratio of number of grants to total number of patents.

Treating narcolepsy with cataplexy using reboxetine

Source: United States Patent and Trademark Office (USPTO). Credit: Axsome Therapeutics Inc

A recently granted patent (Publication Number: US11883408B2) outlines a method for reducing daytime sleepiness in individuals experiencing narcolepsy with cataplexy. The method involves administering a specific dosage of reboxetine daily for at least two weeks to individuals who have experienced at least 7 cataplexy attacks in the week prior to treatment initiation. The effectiveness of the treatment is measured by a reduction in daytime sleepiness, as indicated by the individual's Epworth Sleepiness Scale scores.

The patent details various aspects of the administration of reboxetine, including dosage forms containing polymers, binders, lubricants, diluents, and disintegrants. Different dosage regimens are also specified, such as administering 4 mg of reboxetine twice a day for the first week, followed by adjustments in dosage for subsequent weeks. The method is specifically tailored for individuals with a diagnosis of narcolepsy with cataplexy meeting specific criteria and who exhibit significant daytime sleepiness, as indicated by an Epworth Sleepiness Scale score exceeding 10 prior to treatment initiation. This patent provides a structured approach to addressing daytime sleepiness in individuals with narcolepsy with cataplexy, offering a potential solution for improving their quality of life.

To know more about GlobalData’s detailed insights on Axsome Therapeutics, buy the report here.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies