Bimekizumab is under clinical development by UCB and currently in Pre-Registration for Ankylosing Spondylitis (Bekhterev’s Disease). According to GlobalData, Pre-Registration drugs for Ankylosing Spondylitis (Bekhterev’s Disease) have a 100% phase transition success rate (PTSR) indication benchmark for progressing into Marketed. GlobalData’s report assesses how Bimekizumab’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Bimekizumab overview

Bimekizumab (Bimzelx) is a humanised IgG1monoclonal antibody produced in a genetically engineered Chinese hamster ovary (CHO) cell line by recombinant DNA technology. It is formulated as solution for injection in pre-filled syringe and pre-filled pen for subcutaneous route of administration. Bimzelx is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy. Bimzelx is indicated for the treatment of plaque psoriasis, generalized pustular psoriasis and psoriatic erythroderma in patients who are not sufficiently responding to existing treatments

Bimekizumab (UCB-4940) is under development for the treatment of immunological diseases including non-radiographic axial spondyloarthritis, ankylosing spondylitis, plaque psoriasis, hidradenitis suppurativa and psoriatic arthritis. The drug candidate is a new biological entity (NBE). It is administered intravenously and as subcutaneous solution. The therapeutic candidate is a humanized monoclonal antibody against IL17A and IL17F. It was also under development for the treatment of non-radiographic axial spondyloarthritis, ankylosing spondylitis, rheumatoid arthritis and moderate to severe active ulcerative colitis (intravenous).

UCB overview

UCB is a biopharmaceutical company that is engaged in the discovery and development of novel medicines and solutions for the treatment of various severe diseases. It strives to develop products for the treatment of neurology and immunology related conditions. The company’s marketed products include Cimzia for ankylosing spondylitis, axial spondyloarthritis, Crohn’s disease, psoriatic arthritis, non-radiographic axial spondyloarthritis and rheumatoid arthritis; Neupro for Parkinson’s disease and restless legs syndrome; Evenity for osteoporosis, and Vimpat, Keppra and Briviact for epilepsy. The company operates through subsidiaries in the US, Japan, Germany, Italy, Spain, France, China, the UK, Ireland, Belgium, Brazil, Russia, India, Mexico, Turkey and other countries. UCB is headquartered in Brussels, Brussels-Capital Region, Belgium.

For a complete picture of Bimekizumab’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.