Binimetinib is under clinical development by Pfizer and currently in Phase II for Triple-Negative Breast Cancer (TNBC). According to GlobalData, Phase II drugs for Triple-Negative Breast Cancer (TNBC) have a 25% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Binimetinib’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Binimetinib (Mektovi) is a halobenzoic acid derivative, acts as anticancer agent. It is formulated as film coated tablets and coated tablets for oral route of administration. Mektovi is indicated for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation and BRAF mutant colorectal cancer.
Binimetinib (MEK-162, ARRY-162) is under development for the treatment of solid tumors including advanced, unresectable or metastatic cutaneous melanoma, metastatic thyroid cancer, triple-negative breast cancer, metastatic colorectal cancer, metastatic uveal melanoma, relapsed or refractory acute myeloid leukemia and acute lymphocytic leukemia, metastatic biliary tract carcinoma including intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma and gallbladder carcinoma, chronic myelocytic leukemia, philadelphia positive acute leukemia, gastrointestinal stromal tumor, hepatocellular carcinoma, advanced non-small cell lung cancer, esophageal cancer and neurofibromatoses type I associated with plexiform neurofibroma. The drug candidate was also under development for the treatment of pancreatic ductal adenocarcinoma, rheumatoid arthritis (RA), metastatic pancreatic adenocarcinoma, small-cell lung cancer, hypertropic cardiomyopathy, ovarian cancer, fallopian tube cancer, peritoneal cancer, melanoma, esophageal cancer, brain metastases and metastatic uveal melanoma.
Pfizer discovers, develops, manufactures and commercializes biopharmaceuticals. The company offers products to treat various conditions such as cardiovascular, metabolic and pain, cancer, inflammation, immune disorders and rare diseases. It also provides sterile injectable pharmaceuticals, biosimilars, active pharmaceutical ingredients (APIs) and contract manufacturing services. Pfizer sells its products through wholesalers, retailers, hospitals, clinics, government agencies and pharmacies. It has major manufacturing facilities in India, China, Japan, Ireland, Italy, Belgium, Germany, Singapore, and the US. The company provides its products in North America, South America, Asia-Pacific, Australia, Europe, Africa and the Middle East. Pfizer is headquartered in New York, the US.
For a complete picture of Binimetinib’s drug-specific PTSR and LoA scores, buy the report here.