BT-1718 is under clinical development by Bicycle Therapeutics and currently in Phase II for Non-Small Cell Lung Cancer. According to GlobalData, Phase II drugs for Non-Small Cell Lung Cancer have a 38% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how BT-1718’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
BT-1718 overview
BT-1718 is under development for the treatment of solid tumors including triple negative breast cancer, squamous non-small cell lung cancer, gastric, non-small cell lung cancer, bladder, esophageal squamous cell carcinoma and sarcoma. It is administered through the intravenous route. The drug comprises of bicyclic peptide conjugated to the maytansinoid toxin. It is developed based on bicyclic peptide technology composed of peptides in combination with a matrix of different linkers for the delivery of a cytotoxic payload. The peptide acts by targeting cells expressing membrane type 1 matrix metalloproteinase (MMP14). It is developed based on bicycle toxin conjugate technology.
Bicycle Therapeutics overview
Bicycle Therapeutics is a biotechnology company. It develops bicyclic peptides and Medicines for the treatment of cancers and other debilitating diseases. The company’s Bicycle conjugates include BT1718, BT5528, and BT8009; and Immuno-Oncology offers BT7480, BT7401, and BT7455. Bicycle Therapeutics proprietary bicyclic peptide technology enables the systematic cyclisation of peptides and helps to identify bicycles that provide antibody-like affinity and selectivity in a much smaller chemically synthesized molecule. The company operates with other biotechnology companies for the development of bicyclic peptide inhibitors for the treatment of ophthalmic diseases such as diabetic macular edema, renal elimination, versatility for multimerization and conjugation. It works in collaboration with Cancer Research UK(CRUK), and AstraZeneca Plc in the areas of oncology, respiratory, cardiovascular, and metabolic diseases, among others. Bicycle Therapeutics is headquartered in Cambridge, Cambridgeshire, the UK.
For a complete picture of BT-1718’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
