Ceralasertib is under clinical development by AstraZeneca and currently in Phase II for Metastatic Castration-Resistant Prostate Cancer (mCRPC). According to GlobalData, Phase II drugs for Metastatic Castration-Resistant Prostate Cancer (mCRPC) have a 33% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Ceralasertib’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Ceralasertib overview

Ceralasertib is under development for the treatment of head and neck cancer squamous cell carcinoma, HER-2 negative breast cancer, non-small cell lung cancer, advanced biliary tract cancer, endometrial cancer, cervical cancer, uterine cancer, small cell lung cancer, chronic myelomonocytic leukemia, metastatic hormone refractory (castration resistant, androgen-independent) prostate cancer, metastatic colorectal cancer, salivary gland cancer, myelodysplastic syndrome, homologous-recombination deficient (HRD) of adenocarcinoma of the gastroesophageal junction, ovarian cancer, peritoneal cancer, fallopian tube cancer, refractory solid tumors including lung adenocarcinoma, metastatic renal cell carcinoma, urothelial cell carcinoma, pancreatic cancer, other solid tumors. The drug candidate is administered through oral route in the form of film coated tablet and gelatin coated capsule. It targets ataxia telangiectasia and rad3 related (ATR) kinase.

It was also under development for the treatment of metastatic triple negative breast cancer, prolymphocytic leukemia (PLL), Burkitt lymphoma, acute lymphocytic leukemia, hairy cell leukemia (HCL), relapsed/refractory chronic lymphocytic leukemia (CLL), non-hodgkin's lymphoma, indolent  b-cell lymphoma and B cell lymphomas, metastatic melanoma.

AstraZeneca overview

AstraZeneca is a biopharmaceutical company, which is focused on discovery, production and commercialization of a range of prescription drugs. It develops products related to therapy areas such as respiratory, cardiovascular, renal and metabolic diseases, cancer, autoimmune, infection and neurological diseases. The company’s product portfolio includes biologics, prescription pharmaceuticals and vaccines. AstraZeneca sells its products through wholly- owned local marketing companies, distributors and local representative offices. The company markets its products to primary care and specialty care physicians. The company operates in Europe, the Americas, Asia, Africa and Australasia. AstraZeneca is headquartered in Cambridge, Cambridgeshire, the UK.

For a complete picture of Ceralasertib’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 22 April 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.