CFI-402257 is under clinical development by Treadwell Therapeutics and currently in Phase II for Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer). According to GlobalData, Phase II drugs for Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer) have a 48% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how CFI-402257’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

CFI-402257 overview

CFI-402257 is under development for the treatment of solid tumors, lung cancer and ER+/Her2 negative breast cancer. It is a small molecule. The drug candidate is administered orally in the form of capsule. It belongs to pyrazolo-pyrimidines class. The drug candidate targets tyrosine threonine (TTK/MPS1) protein kinase.

It was also under development for the treatment of castrate refractory prostate cancer.

Treadwell Therapeutics overview

Treadwell Therapeutics is a clinical-stage biotechnology company that develops novel therapeutics for highly aggressive cancers. The company’s pipeline products include small cell therapeutic products, biologic therapy and T-cell receptor (TCR) based cell therapy products. Its products are used in various therapeutic areas which include solid and liquid tumors, breast cancer, prostate cancer, myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML), among others. Treadwell Therapeutics leverages deep mechanistic insights and internal discovery tools to uncover novel targets and translate those insights into clinical candidates. The company operates in the US, Canada and Hong Kong. Treadwell Therapeutics is headquartered in New York City, New York, the US.

For a complete picture of CFI-402257’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.