Cyclerion Therapeutics. has been granted a patent for novel processes to prepare high-purity compounds that stimulate soluble guanylate cyclase (sGC). The methods allow for large-scale production and include novel intermediates, enhancing manufacturing efficiency and stability of the resulting compounds. GlobalData’s report on Cyclerion Therapeutics gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Cyclerion Therapeutics, Peptide pharmacophores was a key innovation area identified from patents. Cyclerion Therapeutics's grant share as of June 2024 was 39%. Grant share is based on the ratio of number of grants to total number of patents.
Process for preparing soluble guanylate cyclase stimulators
The granted patent US12030874B2 outlines a series of processes for preparing specific chemical compounds, particularly those represented by Formula IB, IC, and ID. The claims detail various methods for synthesizing these compounds, including the use of specific reactants and conditions. Notably, the processes involve the reaction of dibromopyrimidine and carboxylic acids, as well as the use of n-butyllithium as a base. The patent also specifies the preparation of compound derivatives and includes crystallization steps to yield distinct crystalline forms, such as Form B of compound ID.
Additionally, the patent describes a crystallization process that involves dissolving the compound in a solvent mixture of acetonitrile and water, followed by a series of heating, filtering, and cooling steps to achieve the desired crystalline form. The claims further elaborate on the use of N,O-dimethylhydroxylamine and various acids in the synthesis process, specifying conditions such as the use of hydrochloric acid or glacial acetic acid. The detailed methodologies provided in the claims aim to enhance the efficiency and specificity of synthesizing these chemical compounds, which may have applications in various fields, including pharmaceuticals and materials science.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
