Dactolisib tosylate is under clinical development by Adicet Bio and currently in Phase II for Parkinson’s Disease. According to GlobalData, Phase II drugs for Parkinson’s Disease have a 41% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Dactolisib tosylate’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Dactolisib tosylate overview
RTB-101 is under development for the treatment of aging-related immunosenescence, illness associated with respiratory tract infection, aging-related organ failure/dysfunction, TORC1 / autophagy-related diseases, Parkinson's disease, infections including urinary tract infections, neuroblastoma, HER2 positive metastatic breast cancer and coronavirus disease 2019 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is a small molecule administered by oral route. The drug candidate acts by targeting P13K and mTORC1.
It was also under development for solid tumors such as hormone receptor positive, HER2 negative, metastatic breast cancer, advanced or metastatic breast cancer, pancreatic neuroendocrine tumors, transitional cell carcinoma, advanced renal cell carcinoma (RCC), advanced or metastatic endometrial cancer, metastatic hormone-refractory prostate cancer, heart failure with preserved ejection fraction, and perivascular epithelioid cell tumors.
Adicet Bio overview
Adicet Bio, formerly resTORbio, is a clinical stage biotechnology company, discovers and develops allogeneic gamma delta T cell therapies for cancer and other diseases. The company offers gamma delta T cells engineered with chimeric antigen receptors and chimeric adaptors to enhance selective tumor targeting, facilitate innate and adaptive anti-tumor immune response, and enhance persistence for durable activity in patients. Its lead product in pipeline includes ADI-001, which is in Phase I clinical study for the treatment of non-Hodgkin’s lymphoma. The company also develops ADI-002, which is undergoing preclinical studies for the treatment of various solid tumors; and ADI-925, a novel engineered CAd gamma delta T cell product candidate targeting tumor stress ligands. Adicet Bio is headquartered in Boston, Massachusetts, the US.
For a complete picture of Dactolisib tosylate’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
