Dong-A Socio has patented technology for labeling antibodies with specific chemical groups, ensuring high uniformity and maintaining antibody functions. The innovation allows site-specific labeling without complex processes, preserving binding affinity and half-life. GlobalData’s report on Dong-A Socio gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Dong-A Socio, was a key innovation area identified from patents. Dong-A Socio's grant share as of February 2024 was 44%. Grant share is based on the ratio of number of grants to total number of patents.
Site-specific labeling of antibodies with chemical functional groups
A recently granted patent (Publication Number: US11896675B2) discloses a modified antibody or its fragment that includes a bio-orthogonal click chemistry functional group. The modified antibody contains one or more modified heavy chains, each with a modified lysine residue at the 248 position of the heavy chain amino acid sequence. Importantly, the modified lysine residue must have a bio-orthogonal click chemistry functional group at the terminal end, excluding specific bio-reactive functional groups like hydroxy, carboxyl, thiol, amino, and aldehyde groups.
Furthermore, the patent claims specify the structure of the modified lysine residue, the composition of the modified heavy chain amino acid sequence, and the permissible variations in the chemical structure of the bio-orthogonal click chemistry functional group. The functional group is crucial for enabling the modified antibody to participate in click chemistry reactions such as Huisgen 1,3-dipolar cycloaddition and Diels-Alder reaction. Various options for the bio-orthogonal click chemistry functional group are provided, including the azide group, tetrazine group, dibenzocyclooctyne group, and norbornene group. This patent aims to protect the unique modifications and compositions that enhance the functionality and specificity of antibodies for potential applications in research, diagnostics, and therapeutics.
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