The Double Homeobox Protein 4 pipeline drugs market research report outlays comprehensive information on the Double Homeobox Protein 4 targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA), and molecule type. GlobalData’s report assesses the drugs in the Double Homeobox Protein 4 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline. Buy the report here.
The report also covers products from therapy areas such as Musculoskeletal Disorders which include the indications Facioscapulohumeral Muscular Dystrophy (FSHD). It also reviews key players involved in Double Homeobox Protein 4 targeted therapeutics development with respective active and dormant or discontinued products.
The Double Homeobox Protein 4 pipeline targets constitutes close to 16 molecules. Out of which, approximately 12 molecules are developed by companies and the remaining by the universities/institutes. The molecules developed by companies in Phase II, Preclinical, and Discovery stages are 2, 8, and 2 respectively. Similarly, the universities portfolio in Preclinical, and Discovery comprises 2, and 2 molecule.
Double Homeobox Protein 4 overview
Double homeobox protein 4 (DUX4) is a transcription factor that is selectively and transiently expressed in cleavage-stage embryos. It binds to double-stranded DNA elements with the consensus sequence 5′-TAATCTAATCA-3′, and to chromatin containing histone H3 acetylated at ‘Lys-27’ (H3K27ac) and promotes deacetylation of H3K27ac. In parallel, it binds to chromatin that lacks histone H3 acetylation at ‘Lys-27’ (H3K27ac) and recruits EP300 and CREBBP to promote acetylation of histone H3 at ‘Lys-27’ at new sites.
For a complete picture of Double Homeobox Protein 4’s drug pipeline, buy the report here.
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