EMB-07 is under clinical development by EpimAb Biotherapeutics and currently in Phase I for Chronic Lymphocytic Leukemia (CLL). According to GlobalData, Phase I drugs for Chronic Lymphocytic Leukemia (CLL) have a 69% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how EMB-07’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
EMB-07 overview
EMB-07 is under development for the treatment of hematologic malignancies, metastatic solid tumors limiting to triple-negative breast cancer, lung adenocarcinoma, ovarian cancer, pancreatic cancer, colorectal cancer, gastric cancer, prostate cancer, bladder cancer, uterus cancer and relapse and refractory diffuse large b-cell lymphoma, mantle cell lymphoma and chronic lymphocytic leukemia. The therapeutic candidate is a T cell redirecting bi-specific monoclonal antibody. It acts by targeting tumor associated antigen (TAA), cells expressing inactive tyrosine protein kinase transmembrane receptor ROR1 (ROR1) and CD3 expressed on T-cells. and is being developed based on FIT-Ig (Fabs-In-Tandem Immunoglobulin) technology. The drug candidate is administered through intravenous route.
EpimAb Biotherapeutics overview
EpimAb Biotherapeutics (EpimAb) is an independent biopharmaceutical research and development company that develops bispecific antibody therapeutics with a focus on immune-oncology. Its lead product candidate EMB-01, which is in preclinical development, is a bispecific antibody that targets the epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (cMET). EpimAb harnesses Fabs-In-Tandem Immunoglobulin (FIT-Ig) technology, which integrates the functions of two parental antibodies into one single molecule to develop its product portfolio. The company works in collaboration with Kymab, Innovent Biologics and Zhejiang Teruisi Biopharmaceutical to develop bispecific antibody programs. EpimAb is headquartered in Shanghai, China.
For a complete picture of EMB-07’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
