FT-576 is a gene-modified cell therapy commercialized by Fate Therapeutics, with a leading Phase I program in Relapsed Multiple Myeloma. According to Globaldata, it is involved in 1 clinical trial, which is ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of FT-576’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for FT-576 is expected to reach an annual total of $7 mn by 2039 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
FT-576 Overview
FT-576 is under development for the treatment of relapsed / refractor multiple myeloma. The therapeutic candidate constitutes of induced pluripotent stem cell (iPSC)-derived chimeric antigen receptor-B-cell maturation antigen (CAR-BCMA) natural killer (NK) cells expressing, IL-15 receptor and a high-affinity, non-cleavable CD16 (hnCD16) Fc receptor, that are knocked out of CD38 gene. It is developed based on iPSC technology. It is administered through parenteral route.
Fate Therapeutics Overview
Fate Therapeutics is a biopharmaceutical company that develops programmed cellular therapies for cancer and immune disorders. The company’s pipeline includes various off-the-shelf, iPSC-derived cellular immunotherapies for the treatment of several hematological malignancies and advanced solid tumors. Its pipeline products also include a donor-derived cell product candidate for the treatment of hematological malignancies. Fate uses its proprietary human-induced pluripotent stem cell (iPSC) platform for product development. The company also has research collaborations with companies, academic centers and medical centers for the advancement of products and technologies. Fate Therapeutics is headquartered in San Diego, California, the US.
The company reported revenues of (US Dollars) US$63.5 million for the fiscal year ended December 2023 (FY2023), a decrease of 34% over FY2022. The operating loss of the company was US$190.5 million in FY2023, compared to an operating loss of US$308.4 million in FY2022. The net loss of the company was US$160.9 million in FY2023, compared to a net loss of US$281.7 million in FY2022.
For a complete picture of FT-576’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
