Gamida Cell has patented a method for expanding transplantable NK cell fractions for cancer treatment. The process involves culturing, supplementing, harvesting, washing, and concentrating the cells before storing for infusion into human subjects. The method aims to improve cell transplant and infusion outcomes for cancer and other diseases. GlobalData’s report on Gamida Cell gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Gamida Cell, T-cell culturing was a key innovation area identified from patents. Gamida Cell's grant share as of January 2024 was 35%. Grant share is based on the ratio of number of grants to total number of patents.
A recently granted patent (Publication Number: US11834677B2) discloses a method for preparing a transplantable NK cell fraction for transplantation into a human subject over 18 years of age. The method involves ex vivo culturing a CD3-depleted NK cell fraction under specific conditions, including the addition of nutrients, serum, IL-15, and nicotinamide. The cultured cells are then supplemented and harvested in two portions, with the first portion comprising about 50% of the expanded NK cell fraction. These portions are washed, concentrated, reconstituted, and stored at room temperature before infusion into the subject, ensuring specific parameters are met for cell viability and safety.
Furthermore, the method outlined in the patent specifies the requirements for the NK cell fraction, including HLA matching criteria, absence of recipient donor-specific anti-HLA antibodies, and a specific percentage of CD56+/CD3- cells. The washed and concentrated portions of the expanded NK cell fraction must meet certain parameters, such as cell composition, viability, and absence of contaminants, to ensure safe and effective transplantation. By following this method, researchers and healthcare professionals can prepare a transplantable NK cell fraction for therapeutic use in patients in need, adhering to strict guidelines for cell quality and safety.
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