Ginkgo Bioworks has been granted a patent for gene therapy compositions and methods to treat NPC1 using Adeno-associated virus (AAV) vectors. The patent includes a specific AAV vector with a capsid protein subunit sequence and a transfer cassette encoding NPC1 protein. GlobalData’s report on Ginkgo Bioworks gives a 360-degree view of the company including its patenting strategy. Buy the report here.
According to GlobalData’s company profile on Ginkgo Bioworks, was a key innovation area identified from patents. Ginkgo Bioworks's grant share as of February 2024 was 26%. Grant share is based on the ratio of number of grants to total number of patents.
Gene therapy composition for treating npc1 using aav vectors
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A recently granted patent (Publication Number: US11905523B2) discloses an adeno-associated virus (AAV) vector designed for gene therapy applications. The vector includes a protein capsid with a specific capsid protein subunit sequence and encapsulates a nucleic acid containing a transfer cassette. This transfer cassette consists of various elements including inverted terminal repeats, a promoter, a transgene encoding a Niemann-Pick intracellular cholesterol transporter 1 (NPC1) protein, a polyadenylation signal, and additional sequences.
Furthermore, the AAV vector may also contain an intronic sequence, specific sequences for the terminal repeats, a chicken ß-actin (CBA) promoter, and a human NPC1 protein sequence. The vector is designed for treating conditions such as Neimann-Pick Disease Type C in human subjects. The patent also covers compositions containing the AAV vector and methods for administering the vector to individuals in need of treatment, particularly those with the specified disease.
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