Ginkgo Bioworks has been granted a patent for gene therapy compositions and methods to treat NPC1 using Adeno-associated virus (AAV) vectors. The patent includes a specific AAV vector with a capsid protein subunit sequence and a transfer cassette encoding NPC1 protein. GlobalData’s report on Ginkgo Bioworks gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Ginkgo Bioworks, was a key innovation area identified from patents. Ginkgo Bioworks's grant share as of February 2024 was 26%. Grant share is based on the ratio of number of grants to total number of patents.

Gene therapy composition for treating npc1 using aav vectors

Source: United States Patent and Trademark Office (USPTO). Credit: Ginkgo Bioworks Holdings Inc

A recently granted patent (Publication Number: US11905523B2) discloses an adeno-associated virus (AAV) vector designed for gene therapy applications. The vector includes a protein capsid with a specific capsid protein subunit sequence and encapsulates a nucleic acid containing a transfer cassette. This transfer cassette consists of various elements including inverted terminal repeats, a promoter, a transgene encoding a Niemann-Pick intracellular cholesterol transporter 1 (NPC1) protein, a polyadenylation signal, and additional sequences.

Furthermore, the AAV vector may also contain an intronic sequence, specific sequences for the terminal repeats, a chicken ß-actin (CBA) promoter, and a human NPC1 protein sequence. The vector is designed for treating conditions such as Neimann-Pick Disease Type C in human subjects. The patent also covers compositions containing the AAV vector and methods for administering the vector to individuals in need of treatment, particularly those with the specified disease.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies