Hisamitsu Pharmaceutical has been granted a patent for a method to quantitatively determine amphetamine carbamate in drug-containing polymer matrices. The process involves separating components, converting amphetacarbamate to carbonate, and quantifying both the carbonate and the original amphetacarbamate based on stoichiometric relationships. GlobalData’s report on Hisamitsu Pharmaceutical gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Hisamitsu Pharmaceutical, Microneedles for transdermal drug delivery was a key innovation area identified from patents. Hisamitsu Pharmaceutical's grant share as of June 2024 was 53%. Grant share is based on the ratio of number of grants to total number of patents.
Quantitative determination of amphetammonium-amphetacarbamate in polymers
The granted patent US11976026B2 outlines a method for quantitatively determining the amount of amphetacarbamate in a drug-containing polymer matrix that includes amphetamine and polymer components. The method involves several key steps: first, the polymer matrix is processed with an organic solvent to separate the polymer components from the amphetamine and any amphetacarbamate, resulting in a solution containing these substances. Next, this solution is treated with a source of basic hydroxide ions under an inert atmosphere, which converts any amphetacarbamate present into carbonate reaction products. The final steps involve quantifying the amount of carbonate produced, which allows for the determination of the original amphetacarbamate content based on a defined stoichiometric relationship.
The patent further specifies various conditions and materials that can be used throughout the process. For instance, the source of basic hydroxide ions may include potassium hydroxide, sodium hydroxide, or lithium hydroxide. The method can also involve immersing the polymer matrix in an organic solvent, such as methanol, and may include the addition of water to facilitate the precipitation of polymer components while keeping the amphetamine and amphetacarbamate in solution. Additionally, the method allows for the use of ion chromatography to separate and quantify the carbonate ions, with detection achieved through conductivity measurement. The claims also encompass specific types of amphetamine-containing polymer matrices, including those used in transdermal delivery systems, and detail the stoichiometric relationships that guide the quantification process.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
