IFx-Hu20 is under clinical development by TuHURA Biosciences and currently in Phase I for Cutaneous Squamous Cell Carcinoma (cSCC). According to GlobalData, Phase I drugs for Cutaneous Squamous Cell Carcinoma (cSCC) have an 87% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how IFx-Hu20’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

IFx-Hu20 overview

IFx-Hu20 is under development for the treatment of cutaneous melanoma, Merkel cell carcinoma, basal cell carcinoma, non-melanoma skin cancers and cutaneous squamous cell carcinoma. The therapeutic candidate is administered through intralesional route. It comprises of plasmid DNA coding for Emm55 Streptococcal antigen. It is developed based on ImmuneFx technology. The therapeutic candidate is composed of the drug substance pAc/emm55 (pDNA) complexed with the two excipients in vivo-jetPEI (linear polyethylenimine), a transfection reagent, and dextrose, a pDNA/polyethylenimine complex stabilizer.

It was also under development for the treatment of colorectal cancer, gastric cancer and head and neck cancer.

TuHURA Biosciences overview

TuHURA Biosciences, formerly Morphogenesis, is a pharmaceutical company that carries out phase 3 registration-stage immuno-oncology company developing novel technologies. The company product pipeline includes the IFx-2.0 cancer vaccine and the IFx-3.0 cancer vaccine. TuHURA Biosciences technology platform includes immune Fx or IFx personalized cancer vaccine technology designed to trick the body’s immune system and bi-functional antibody-drug conjugates (ADCs) that target myeloid-derived suppressor cells. The company has operations in the US. TuHURA Biosciences is headquartered in Tampa, Florida, the US.

For a complete picture of IFx-Hu20’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.