The pharmaceutical industry continues to be a hotbed of innovation, with activity driven by the evolution of new treatment paradigms, and the gravity of unmet needs, as well as the growing importance of technologies such as pharmacogenomics, digital therapeutics, and artificial intelligence. In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Innovation in Pharmaceuticals: Peptide nano-particle conjugates. Buy the report here.

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However, not all innovations are equal and nor do they follow a constant upward trend. Instead, their evolution takes the form of an S-shaped curve that reflects their typical lifecycle from early emergence to accelerating adoption, before finally stabilising and reaching maturity.

Identifying where a particular innovation is on this journey, especially those that are in the emerging and accelerating stages, is essential for understanding their current level of adoption and the likely future trajectory and impact they will have.

110 innovations will shape the pharmaceutical industry

According to GlobalData’s Technology Foresights, which plots the S-curve for the pharmaceutical industry using innovation intensity models built on over 756,000 patents, there are 110 innovation areas that will shape the future of the industry.

Within the emerging innovation stage, cell therapy for ocular disorders, coronavirus vaccine components, and DNA polymerase compositions are disruptive technologies that are in the early stages of application and should be tracked closely. Adeno-associated virus vectors, alcohol dehydrogenase compositions, and antibody serum stabilisers are some of the accelerating innovation areas, where adoption has been steadily increasing. Among maturing innovation areas are anti-influenza antibody compositions and anti-interleukin-1, which are now well established in the industry.

Innovation S-curve for the pharmaceutical industry

Peptide nano-particle conjugates is a key innovation area in the pharmaceutical industry

By tagging peptides with nanoparticles, peptide nano-particle conjugates allow enhanced control over their biological behaviour, overcoming intrinsic limitations of the individual materials. The conjugation of antimicrobial peptides (AMPs) with nanoparticles increases the local concentration of the peptide at the site of delivery, improving peptide targeting. Silver nanoparticles (AgNPs) and AMP conjugates exhibit increased stability with higher activity than AMPs or AgNPs separately.

GlobalData’s analysis also uncovers the companies at the forefront of each innovation area and assesses the potential reach and impact of their patenting activity across different applications and geographies. According to GlobalData, there are 260+ companies, spanning technology vendors, established pharmaceutical companies, and up-and-coming start-ups engaged in the development and application of peptide nano-particle conjugates.

Key players in peptide nano-particle conjugates – a disruptive innovation in the pharmaceutical industry

‘Application diversity’ measures the number of different applications identified for each relevant patent and broadly splits companies into either ‘niche’ or ‘diversified’ innovators.

‘Geographic reach’ refers to the number of different countries each relevant patent is registered in and reflects the breadth of geographic application intended, ranging from ‘global’ to ‘local’.

Patent volumes related to peptide nano-particle conjugates

Company Total patents (2010 - 2022) Premium intelligence on the world's largest companies
F. Hoffmann-La Roche 945 Unlock Company Profile
Takeda Pharmaceutical 800 Unlock Company Profile
Selecta Biosciences 513 Unlock Company Profile
Novo Nordisk Foundation 346 Unlock Company Profile
Merck & Co 322 Unlock Company Profile
Regeneron Pharmaceuticals 305 Unlock Company Profile
Johnson & Johnson 277 Unlock Company Profile
Pfizer 275 Unlock Company Profile
Amgen 255 Unlock Company Profile
Mitsubishi Chemical Group 218 Unlock Company Profile
AbbVie 194 Unlock Company Profile
E. Merck 168 Unlock Company Profile
3B Future Holding 137 Unlock Company Profile
Baxter International 135 Unlock Company Profile
Bristol-Myers Squibb 132 Unlock Company Profile
GSK 127 Unlock Company Profile
Ipsen 119 Unlock Company Profile
Ferring Holding 112 Unlock Company Profile
Sanofi 112 Unlock Company Profile
LFB 107 Unlock Company Profile
Biogen 104 Unlock Company Profile
Adocia 103 Unlock Company Profile
Grifols 103 Unlock Company Profile
Bayer 99 Unlock Company Profile
Celltrion 90 Unlock Company Profile
Melinta Therapeutics 90 Unlock Company Profile
Arecor 86 Unlock Company Profile
CSL 86 Unlock Company Profile
Fresenius 85 Unlock Company Profile
AstraZeneca 77 Unlock Company Profile
NoNO 76 Unlock Company Profile
Xeris Biopharma Holdings 75 Unlock Company Profile
UCB 73 Unlock Company Profile
Eli Lilly and 69 Unlock Company Profile
Wockhardt 67 Unlock Company Profile
DuPont de Nemours 61 Unlock Company Profile
C. H. Boehringer Sohn 59 Unlock Company Profile
Otsuka Holdings 59 Unlock Company Profile
Novartis 54 Unlock Company Profile
LG 50 Unlock Company Profile
Sandberg Development 48 Unlock Company Profile
Cidara Therapeutics 48 Unlock Company Profile
Asahi Kasei 46 Unlock Company Profile
Bausch Health Companies 45 Unlock Company Profile
BioNet Holding 44 Unlock Company Profile
Octapharma 43 Unlock Company Profile
Zydus Lifesciences 43 Unlock Company Profile
AiCuris Anti-infective Cures 42 Unlock Company Profile
Compagnie Merieux Alliance 42 Unlock Company Profile
Chongqing Runze Pharmaceutical 42 Unlock Company Profile

Source: GlobalData Patent Analytics

F. Hoffmann-La Roche is the leading patent filer in the peptide nano-particle conjugates space. The company develops drugs and diagnostics to treat major diseases. It provides medicines for the treatment of cancer, auto-immune diseases, central nervous system disorders, ophthalmological disorders, infectious diseases, and respiratory diseases. Takeda Pharmaceutical and Selecta Biosciences are the other key patent filers of peptide nano-particle conjugates.

In terms of application diversity, Onxeo is the top company, followed by Cerion and StemBios Technologies. By means of geographic reach, the German Cancer Research Center holds the top position. Halozyme Therapeutics and Soligenix stand in second and third positions, respectively.

To further understand the key themes and technologies disrupting the pharmaceutical industry, access GlobalData’s latest thematic research report on Pharmaceutical.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Patent Analytics tracks patent filings and grants from official offices around the world. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.