The pharmaceutical industry continues to be a hotbed of innovation, with activity driven by the evolution of new treatment paradigms, the gravity of unmet medical needs, as well as the growing importance of technologies such as pharmacogenomics, digital therapeutics, and artificial intelligence. In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Biosimilars in Pharmaceuticals: Recombinant antibodies for cytotoxic T-cells.

According to GlobalData’s Technology Foresights, which uses over 756,000 patents to analyse innovation intensity for the pharmaceutical industry, there are 110 innovation areas that will shape the future of the industry. 

Recombinant antibodies for cytotoxic T-cells is a key innovation area in biosimilars 

Cytotoxic T-cells, also called killer T-cells or cytotoxic T lymphocytes, are a type of white blood cell (WBC) or lymphocyte. Cytotoxic T-cells play an important role in the body’s immune defence by identifying and eliminating cancer cells, and other pathogens. Monoclonal antibodies, especially bi-specific monoclonal antibodies, target the T-cell Receptor (TCR) complex and activate these cells, directing them toward cancer and infected cells, killing them.

GlobalData’s analysis also uncovers the companies at the forefront of each innovation area and assesses the potential reach and impact of their patenting activity across different applications and geographies.  According to GlobalData, there are 290+ companies, spanning technology vendors, established pharmaceutical companies, and up-and-coming start-ups engaged in the development and application of recombinant antibodies for cytotoxic T-cells. 

Key players in recombinant antibodies for cytotoxic T-cells – a disruptive innovation in the pharmaceutical industry  

‘Application diversity’ measures the number of different applications identified for each relevant patent and broadly splits companies into either ‘niche’ or ‘diversified’ innovators. 

‘Geographic reach’ refers to the number of different countries each relevant patent is registered in and reflects the breadth of geographic application intended, ranging from ‘global’ to ‘local’. 

Patent volumes related to recombinant antibodies for cytotoxic T-cells

Company Total patents (2010 - 2021) Premium intelligence on the world's largest companies
Bristol-Myers Squibb 923 Unlock company profile
Cellectis 534 Unlock company profile
Memorial Sloan Kettering Cancer Center 520 Unlock company profile
Gilead Sciences 420 Unlock company profile
bluebird bio 407 Unlock company profile
Autolus 366 Unlock company profile
Amgen 331 Unlock company profile
City of Hope 320 Unlock company profile
Fred Hutchinson Cancer Research Center 297 Unlock company profile
Eureka Therapeutics 288 Unlock company profile
Miltenyi Biotec 227 Unlock company profile
CARsgen Therapeutics 198 Unlock company profile
Seattle Children's Hospital 188 Unlock company profile
Pfizer 175 Unlock company profile
Regeneron Pharmaceuticals 169 Unlock company profile
CRISPR Therapeutics 138 Unlock company profile
ImmunityBio 135 Unlock company profile
Nanjing Legend Biotech 131 Unlock company profile
BioNTech 127 Unlock company profile
TCR2 Therapeutics 123 Unlock company profile
United States Of America 117 Unlock company profile
Precision Biosciences 106 Unlock company profile
Biogen 106 Unlock company profile
C. H. Boehringer Sohn 104 Unlock company profile
Immatics 101 Unlock company profile
Alpine Immune Sciences 99 Unlock company profile
Aleta Biotherapeutics 99 Unlock company profile
Allogene Therapeutics 93 Unlock company profile
Innovative Cellular Therapeutics 92 Unlock company profile
Xencor 88 Unlock company profile
Massachusetts General Hospital 86 Unlock company profile
Inhibrx 86 Unlock company profile
F. Hoffmann-La Roche 85 Unlock company profile
PT Soho Global Health Tbk 81 Unlock company profile
Poseida Therapeutics 81 Unlock company profile
Precigen 79 Unlock company profile
Merck & Co 77 Unlock company profile
iCell Gene Therapeutics 68 Unlock company profile
Fate Therapeutics 65 Unlock company profile
Bellicum Pharmaceuticals 65 Unlock company profile
Sangamo Therapeutics 64 Unlock company profile
Novartis 62 Unlock company profile
GSK 62 Unlock company profile
EXUMA Biotech 57 Unlock company profile
TRON gGmbH 54 Unlock company profile
Editas Medicine 52 Unlock company profile
Genscript Biotech 51 Unlock company profile
AbbVie 50 Unlock company profile
Johnson & Johnson 49 Unlock company profile
CytoImmune Therapeutics 49 Unlock company profile

Source: GlobalData Patent Analytics

Amgen, one of the leading players, has a large presence within the biologics market. Its Bispecific T-cell Engager (BiTE) technology is a cornerstone in the development of bi-specific antibodies. BiTE technology is designed to overcome cancer cells’ evasion of the immune system by engaging patients’ own T cells to directly target cancer cells. BiTE molecules comprise two flexibly-linked, single-chain antibodies, with one designed to bind specifically to a selected tumour-associated antigen and the other to bind to CD3 antigens found on T cells.

In terms of application diversity, Fate Therapeutics is the leading company, followed by Immatics and Biogen. By means of geographic reach, Boehringer holds the top position. Amgen and Pfizer are in the second and third positions, respectively.

To further understand the key themes and technologies disrupting the pharmaceutical industry, access GlobalData’s latest thematic research report on Pharmaceutical.

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Patent Analytics tracks patent filings and grants from official offices around the world. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.