Intra-Cellular Therapies has developed a new patent for stable amorphous solid dispersions of ITI-007 tosylate salt, with stabilizing excipients like cellulose acetate phthalate. This innovation opens up possibilities for new pharmaceutical compositions. GlobalData’s report on Intra-Cellular Therapies gives a 360-degree view of the company including its patenting strategy. Buy the report here.
Smarter leaders trust GlobalData
According to GlobalData’s company profile on Intra-Cellular Therapies, Peptide pharmacophores was a key innovation area identified from patents. Intra-Cellular Therapies's grant share as of January 2024 was 34%. Grant share is based on the ratio of number of grants to total number of patents.
Amorphous solid dispersion of iti-007 tosylate salt
The granted patent (Publication Number: US11872223B2) discloses an amorphous solid dispersion containing 1-(4-fluoro-phenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-butan-1-one (ITI-007) tosylate salt along with a stabilizing excipient. The stabilizing excipient can be selected from various options including cellulose acetate phthalate, hydroxypropyl methyl cellulose acetate succinate, and polyvinyl acetate among others. The dispersion may also include an anti-oxidant like tocopherol or a surfactant, and is x-ray amorphous to ensure stability.
Furthermore, the patent covers the manufacturing method of the dispersion, involving dissolving ITI-007 tosylate salt and the stabilizing excipient in suitable solvents like dioxane, methanol, or their mixtures, followed by solvent removal to obtain the amorphous solid dispersion. The resulting dispersion can be used in a pharmaceutical composition with a pharmaceutically acceptable diluent or carrier, in forms like tablets, capsules for oral administration, or depot formulations for long-acting injectables (LAI). The composition's X-ray diffraction pattern is devoid of peaks characteristic of the excipient, ensuring the purity and stability of the dispersion for pharmaceutical applications.
To know more about GlobalData’s detailed insights on Intra-Cellular Therapies, buy the report here.
Premium Insights
From
The gold standard of business intelligence.
Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors.
GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
